ASF1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a small-molecule inhibitor of ASH1L (Absent, small or homeotic discs 1-like protein), a histone methyltransferase. It suppresses ASH1L's activity, leading to a decrease in H3K36 methylation and transcriptional repression of target genes involved in cancer development. | ||||||
9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine | 1380288-87-8 | sc-500607 | 50 mg | $13500.00 | ||
EPZ-5676 is an inhibitor of DOT1L, a histone methyltransferase. It selectively targets DOT1L's enzymatic activity, blocking the methylation of histone H3K79. This inhibition disrupts gene expression programs associated with leukemia, inhibiting cancer cell growth. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
GSK-126 inhibits EZH2 (Enhancer of Zeste Homolog 2), a histone methyltransferase. It disrupts the methyltransferase activity of EZH2, reducing H3K27 methylation and impairing the repression of tumor suppressor genes in cancer cells. | ||||||
CPI-360 | 1802175-06-9 | sc-507464 | 1 mg | $100.00 | ||
CPI-360 is an inhibitor of NSD2 (Nuclear receptor-binding SET domain protein 2), also known as WHSC1 or MMSET. It hampers the methyltransferase activity of NSD2, leading to a decrease in H3K36 methylation and downregulation of oncogenic pathways in multiple myeloma. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 targets G9a/GLP, histone methyltransferases responsible for H3K9 methylation. By inhibiting their activity, UNC0638 disrupts the epigenetic landscape, potentially impacting gene expression relevant to various diseases, including cancer. | ||||||
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
A-366 is a selective inhibitor of G9a/GLP, targeting their histone methyltransferase activity. By blocking H3K9 methylation, A-366 can modulate gene expression patterns and has potential applications in cancer and other diseases. | ||||||