ASB-5 Activators
ASB-5 Activators are chemicals that can modulate the activity of ASB-5, a protein that is part of the ASB family known to function as E3 ubiquitin ligases in the ubiquitin proteasome system. This class of chemicals act by modulating the ubiquitin-proteasome system, a principal mechanism for protein catabolism in cells. The activators included in this class, such as MG132, Velcade, ALLN, and Lactacystin, primarily function as proteasome inhibitors. By blocking the proteasome, these chemicals prevent the degradation of ubiquitinated proteins, which can increase the demand for ubiquitination, leading to a potential enhancement of ASB-5 activity. Other members of the class, such as MLN4924 and NSC697923, disrupt the ubiquitination process more directly by inhibiting enzymes involved in ubiquitin conjugation and processing. These alterations in the ubiquitination balance can lead to changes in the activity of ubiquitin ligases like ASB-5.
In contrast, some members of the ASB-5 activator class, like Nutlin-3 and IU1, target specific components of the ubiquitination machinery. Nutlin-3, for instance, inhibits MDM2, a ubiquitin ligase that targets the tumor suppressor p53 for degradation. By inhibiting MDM2 and stabilizing p53, Nutlin-3 alters the dynamics of the ubiquitination process, which could affect the activity of ASB-5. Similarly, IU1 inhibits USP14, a proteasome-associated deubiquitinating enzyme. By inhibiting USP14, IU1 can modulate the overall ubiquitination dynamics within the cell, which can affect ASB-5 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a potent proteasome and calpain inhibitor. It prevents the degradation of ubiquitin-conjugated proteins, and can increase the overall demand for ubiquitination, possibly enhancing ASB-5 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Velcade is a proteasome inhibitor that impedes the degradation of ubiquitinated proteins. It can enhance ubiquitination demand, potentially leading to increased ASB-5 activity. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 inhibits NEDD8-activating enzyme (NAE), a key component of the neddylation pathway that regulates ubiquitination. This can disrupt ubiquitination balance, possibly affecting ASB-5 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate inhibits the chymotrypsin-like activity of the proteasome and may increase the demand for ubiquitination, possibly enhancing ASB-5 activity. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific and potent inhibitor of the proteasome. It can increase the demand for ubiquitination, potentially enhancing ASB-5 activity. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 inhibits MDM2, a ubiquitin ligase, leading to p53 stabilization. This can alter ubiquitination dynamics, potentially affecting ASB-5 activity. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1 is a specific inhibitor of USP14, a proteasome-associated deubiquitinating enzyme, which can alter overall ubiquitination dynamics, possibly affecting ASB-5 activity. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum inhibitor of deubiquitinating enzymes (DUBs), which can disrupt ubiquitination balance, potentially affecting ASB-5 activity. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 is a potent cell-permeable inhibitor of ubiquitin-activating enzyme E1, which can alter ubiquitination dynamics, possibly affecting ASB-5 activity. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
NSC697923 is a specific inhibitor of the ubiquitin-conjugating enzyme UBE2N, which can disrupt the ubiquitination balance, potentially affecting ASB-5 activity. | ||||||