ARX Activators
ARX, an important transcription factor belonging to the Aristaless-related homeobox gene family, holds significant regulatory influence over embryonic development, particularly within the central nervous system (CNS). Functionally, ARX orchestrates gene expression patterns essential for neuronal differentiation, migration, and the specification of distinct neuronal subtypes during CNS development. Specifically, ARX governs the expression of genes crucial for the development of GABAergic and cholinergic neurotransmitter systems, as well as those encoding ion channels and synaptic proteins pivotal for neuronal function. Through its transcriptional activity, ARX contributes to the establishment of intricate neuronal circuitry and the formation of neural networks requisite for proper CNS function. Dysregulation of ARX expression or function has been linked to various neurodevelopmental disorders, such as X-linked lissencephaly with abnormal genitalia (XLAG) and West syndrome, underscoring its pivotal role in neurodevelopmental processes.
Activation of ARX involves intricate regulatory mechanisms aimed at initiating and sustaining proper neuronal development during embryogenesis. Various signaling pathways and transcriptional co-factors contribute to the activation of ARX in a context-dependent manner. Activation of ARX may occur through phosphorylation events mediated by upstream kinases, which enhance its DNA binding affinity and transcriptional activity, thereby promoting the expression of genes essential for neuronal differentiation and maturation. Additionally, interactions with co-activators and chromatin remodeling complexes may facilitate the recruitment of ARX to specific gene promoters, further enhancing its transcriptional activity and promoting proper neuronal development. Understanding the detailed mechanisms underlying ARX activation offers insights into the regulation of neurodevelopmental processes and provides targets for intervention in neurodevelopmental disorders associated with ARX dysfunction.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
An HDAC inhibitor; can affect chromatin remodeling, potentially influencing ARX expression by altering the transcriptional landscape in neural cells. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences the Wnt signaling pathway; might indirectly modulate ARX through pathways associated with neurodevelopment and neuroplasticity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Affects gene expression; can modulate ARX activity by impacting cellular differentiation and neuronal development processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels; might affect ARX expression through cAMP-responsive elements in neuronal cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor; potentially alters chromatin structure and enhances transcription, indirectly influencing ARX expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor; could indirectly influence ARX by affecting chromatin structure and transcription regulation in neural cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Influences metabolic and inflammatory pathways; could indirectly modulate ARX activity in neuronal cells. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor; could influence ARX indirectly by altering the MAPK pathway, which is involved in neuronal cell differentiation and development. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor; can affect neuronal differentiation and might indirectly influence ARX expression through pathways associated with neurogenesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor; might modulate ARX activity indirectly through the PI3K/Akt pathway, impacting neural development and function. | ||||||