Arp7 Activators
Arp7 Activators encompass a diverse set of chemical compounds that facilitate the enhancement of Arp7's role in the regulation of actin dynamics. Compounds like Jasplakinolide and Phalloidin directly stabilize F-actin, promoting the assembly and maintenance of actin filaments, thereby augmenting Arp7's activity in these processes. Similarly, Calyculin A can indirectly increase Arp7 activity by preventing dephosphorylation of regulatory proteins involved in actin dynamics, while Latrunculin A and Cytochalasin D bind actin monomers and filaments, respectively, disrupting polymerization and prompting the cellular machinery to upregulate Arp7 activity as a compensatory mechanism. CK-666 and Swinholide A exert their effects by inhibiting the Arp2/3 complex and severing actin filaments, leading to potential upregulation of Arp7 to sustain cellular actin architecture.
Arp7 activators, such as Chondramide, Y-27632, and ML-7, indirectly promote Arp7's functional role byinhibiting actin polymerization or altering signaling pathways that impact the actin cytoskeleton, which may enhance Arp7 activity to counterbalance these disruptions. Blebbistatin's inhibition of myosin II and the stabilization of actin filaments by Tropomyosin also contribute to maintaining actin dynamics, potentially enhancing Arp7 activity as part of the cellular response to altered actomyosin interactions. Collectively, these activators, through their targeted effects on actin dynamics and associated signaling pathways, support the enhancement of Arp7-mediated functions, crucial for maintaining cellular integrity and facilitating various cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes F-actin and prevents its depolymerization, which can lead to the enhanced activity of Arp7 by promoting actin polymerization and stabilizing actin filaments, processes where Arp7 is known to play a crucial role. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds and stabilizes F-actin, and by doing so, it may indirectly enhance the activity of Arp7 by maintaining actin filament integrity, thereby facilitating Arp7's role in actin dynamics. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation within the cell. This can indirectly enhance Arp7 activity by affecting the phosphorylation state of proteins involved in the regulation of actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to G-actin, preventing its polymerization. This disruption of actin dynamics can lead to compensatory mechanisms that enhance Arp7's role in actin filament formation and stabilization. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed end of actin filaments, causing depolymerization. This can lead to increased activity of Arp7 as the cell attempts to counteract the destabilization of actin filaments. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which can result in an upregulation of Arp7's activity as a compensatory response to maintain actin filament network dynamics. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and prevents polymerization, potentially leading to an indirect enhancement of Arp7 activity as the cell compensates for the loss of actin filament stability. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase (ROCK), which can lead to changes in actin cytoskeleton dynamics and potentially enhance the activity of Arp7 through downstream effects on actin remodeling. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which may lead to alterations in actin-myosin interactions and indirectly enhance the activity of Arp7 in actin filament formation and stabilization. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits myosin II, which can lead to a rearrangement of the actin cytoskeleton and potentially enhance Arp7 activity as the cell responds to changes in actomyosin dynamics. | ||||||