AROS-29 Activators
TMEM161A activators encompass a diverse range of chemicals, each with a unique mechanism of action that influences pathways and processes that TMEM161A is associated with. Among the activators, Retinoic Acid and Tretinoin stand out due to their direct impact on the retinoic acid signaling pathway. Their ability to modulate retinoic acid receptors and the subsequent cellular response suggests an interaction with TMEM161A, given its inherent response to retinoic acid.
On the other hand, compounds such as UV-C light, Hydroxyurea, Amsacrine, Olaparib, Etoposide, Cisplatin, Vorinostat, Arsenic Trioxide, 5-Azacytidine, and Bleomycin primarily affect the DNA structure or DNA damage response. For instance, UV-C radiation and Cisplatin induce DNA damage, and their induction of the DNA damage response pathway suggests an interaction with proteins involved in this process, including TMEM161A. Similarly, Etoposide, by inhibiting topoisomerase II, introduces DNA breaks and subsequently engages cellular machinery in DNA repair. TMEM161A, with its role in the regulation of the DNA damage stimulus, may find its function modulated under the influence of such DNA-interacting compounds. Moreover, histone deacetylase like Vorinostat impact chromatin remodeling and DNA repair pathways, suggesting an indirect mode of action that might affect TMEM161A. Overall, these activators, through their individual mechanisms on associated pathways, provide a means to influence the function and interplay of TMEM161A within cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can activate the retinoic acid signaling pathway. TMEM161A's response to retinoic acid suggests that its function may be modulated in the presence of this compound. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea induces DNA replication stress leading to DNA damage response. This can influence TMEM161A's role in the regulation of DNA damage stimulus. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine intercalates DNA and affects the DNA damage pathway. Its effect on DNA damage can modulate the function of TMEM161A within the damage response pathway. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor that enhances DNA damage. By affecting the DNA damage response, it may influence TMEM161A which is involved in the regulation of this cellular response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, resulting in DNA damage. Its influence on the DNA damage pathway might affect proteins like TMEM161A that are involved in this pathway. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts leading to DNA damage. Given TMEM161A's role in DNA damage response, its function can be modulated by cisplatin-induced DNA changes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Histone deacetylase inhibitor that affects chromatin remodeling and DNA repair pathways. Its action may influence TMEM161A's role in DNA damage stimulus. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Induces DNA damage and affects the cellular response to DNA damage, potentially modulating TMEM161A's function within this pathway. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Incorporates into DNA, leading to DNA damage. This can affect TMEM161A's role in the regulation of DNA damage stimulus. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Causes DNA breaks and affects DNA repair pathways. Its action on DNA damage pathways can influence TMEM161A's function within these pathways. | ||||||