ARMC7 (Armadillo Repeat Containing 7) inhibitors are a class of chemical compounds that target and inhibit the activity or function of the ARMC7 protein. ARMC7 is a lesser-known member of the armadillo repeat-containing protein family, which is characterized by tandemly repeated armadillo motifs that facilitate protein-protein interactions. These proteins play roles in a variety of cellular processes, including cell signaling, cytoskeletal organization, and the regulation of gene expression. ARMC7 specifically is thought to be involved in complex cellular functions related to scaffolding and facilitating interactions between other proteins. Inhibitors of ARMC7 are designed to disrupt its ability to bind with target proteins, thereby modulating the pathways in which ARMC7 participates.
The chemical structure of ARMC7 inhibitors can vary, but they typically include small molecules or peptides designed to interact with key regions of the ARMC7 protein, such as the armadillo repeat motifs, which are critical for its ability to engage with other cellular proteins. By binding to these regions, the inhibitors can prevent ARMC7 from carrying out its role in protein-protein interactions, affecting the downstream signaling pathways and cellular processes in which it is involved. The study of ARMC7 inhibitors provides valuable insight into the functional role of this protein within the cell, particularly regarding its contribution to structural and signaling networks. Researchers use these inhibitors to explore how ARMC7 influences cellular architecture and protein organization, offering a better understanding of the molecular mechanisms that govern complex protein interactions within various biological contexts.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Inhibits the Wnt/β-catenin pathway by blocking the palmitoleation of Wnt proteins, potentially affecting ARMC7's role in this signaling pathway if present. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Stabilizes axin by inhibiting tankyrase, leading to β-catenin degradation and potentially downregulating ARMC7-related Wnt signaling. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Inhibits Wnt production by blocking Porcupine, thereby potentially affecting ARMC7's association with the Wnt signaling pathway. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
Inhibits Porcupine, an O-acyltransferase required for Wnt signaling, potentially disrupting any ARMC7-mediated Wnt signaling processes. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
A GSK-3β inhibitor that activates Wnt signaling, which could indirectly affect ARMC7 if it is involved in this pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A TGF-β receptor inhibitor that could affect ARMC7 interactions with TGF-β signaling components. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
A JNK inhibitor that might alter ARMC7 functionality if ARMC7 is part of the JNK signaling pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, potentially affecting ARMC7's role in PI3K/Akt signaling if ARMC7 is implicated in this pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could impact ARMC7 levels by preventing its degradation if ARMC7 is regulated by ubiquitination. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor similar to Bortezomib, which could stabilize ARMC7 protein levels by inhibiting proteasomal degradation. |