ARHGAP12 Activators
ARHGAP12 activators represent a category of chemical compounds designed to modulate the activity of the ARHGAP12 protein. ARHGAP12, also known as Rho GTPase-activating protein 12, is a member of the Rho GTPase-activating protein (RhoGAP) family. This family of proteins plays a critical role in the regulation of Rho family GTPases, such as RhoA, Rac1, and Cdc42, which are key regulators of cytoskeletal dynamics, cell migration, and cellular processes involving actin polymerization and myosin-based contractility. ARHGAP12 functions as a negative regulator of these Rho GTPases by accelerating the hydrolysis of GTP to GDP, thereby inactivating them. By targeting ARHGAP12, activators aim to influence the activity of Rho GTPases and, consequently, cellular processes reliant on Rho GTPase signaling.
The modulation of ARHGAP12 activity by activators has significant implications in cellular biology and beyond. Rho GTPases are pivotal in various cellular functions, including cell motility, adhesion, and cell shape regulation. Dysregulation of Rho GTPase signaling is associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, understanding the role of ARHGAP12 activators in regulating Rho GTPases and their downstream effects is critical for unraveling the complex web of cellular processes these proteins control. Research in this area can lead to insights into fundamental cellular mechanisms, and it may provide potential targets for the development of novel interventions in the future.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
It may modulate ARHGAP12 expression during cell differentiation and development, given its role in gene regulation. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-beta could potentially affect ARHGAP12 expression as it is involved in cellular differentiation and proliferation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, forskolin can influence various signaling pathways, which may include those regulating ARHGAP12 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA might alter ARHGAP12 expression by activating protein kinase C and modulating related signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a corticosteroid, dexamethasone might regulate ARHGAP12 expression through its effects on gene regulation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin could influence ARHGAP12 expression in certain cellular contexts, given its role in metabolism and cell signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
This compound might modulate ARHGAP12 expression by affecting Wnt signaling and GSK-3 inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR pathway inhibitor, rapamycin could potentially impact ARHGAP12 expression in the context of cellular growth control. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate may influence ARHGAP12 expression by altering chromatin structure and gene expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an oxidative stress inducer, hydrogen peroxide might affect cellular responses including ARHGAP12 expression. | ||||||