ARF6 Activators
ARF6 Activators belong to a specialized category of proteins and small molecules that play a pivotal role in regulating cellular processes. ARF6, or ADP-ribosylation factor 6, is a member of the ARF family of small GTPases, which act as molecular switches involved in intracellular trafficking and signaling pathways. ARF6 itself is a key regulator of membrane dynamics and is primarily associated with endocytic and exocytic processes within cells. Activators of ARF6 are compounds or proteins that modulate the activity of ARF6, either by promoting its activation to the GTP-bound state or by stabilizing this active conformation, thereby influencing various cellular functions.
At a molecular level, ARF6 Activators typically interact with ARF6 and stimulate its activation by facilitating the exchange of GDP for GTP. This nucleotide exchange process is crucial because it triggers a conformational change in ARF6, allowing it to interact with downstream effectors and initiate specific cellular responses. ARF6, when activated, plays a central role in regulating processes such as endocytosis, vesicular trafficking, membrane recycling, and actin cytoskeleton dynamics. These functions are essential for various cellular events, including cell motility, cytokinesis, and the maintenance of cell surface receptor distribution. Consequently, ARF6 Activators are vital components of the cellular machinery, contributing to the fine-tuning of intracellular processes and enabling cells to respond to extracellular cues efficiently. ARF6 Activators form a diverse group of molecules and proteins that influence cellular dynamics by modulating the activity of ARF6, a critical regulator of intracellular membrane trafficking and signaling. By facilitating ARF6 activation, these molecules play a fundamental role in the coordination of essential cellular processes, contributing to cell homeostasis and responsiveness to environmental cues.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, is known to modulate gene expression by binding to nuclear receptors. It may induce ARF6 expression by promoting transcriptional activities and cell differentiation processes. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a primary female sex hormone, 17β-Estradiol plays a role in regulating gene expression and cell growth. It might induce ARF6 expression through estrogen receptor-mediated signaling pathways, influencing cellular functions in various tissues. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, found in the Coleus forskohlii plant, activates adenylate cyclase, increasing cyclic AMP levels. This upregulation may lead to altered gene expression, potentially including an increase in ARF6 to modulate cellular responses to external stimuli. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, can modulate gene expression and cellular functions through its interaction with glucocorticoid receptors. This interaction might lead to an upregulation of ARF6, impacting processes like inflammation and immune responses. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone, a thiazolidinedione, activates PPAR-γ receptors, influencing glucose and lipid metabolism. This activation may also induce ARF6 expression, playing a role in cellular processes related to metabolism and energy balance. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin regulates glucose metabolism and has broad effects on gene expression. Its interaction with the insulin receptor can activate downstream signaling pathways, potentially leading to an increase in ARF6 expression to modulate cellular uptake of glucose and other molecules. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride has been shown to influence various signaling pathways and gene expression patterns. Its effects might include the induction of ARF6 expression, potentially playing a role in cellular responses to stress and other stimuli. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, influences gene expression through its effects on histone deacetylation. This action can lead to changes in chromatin structure, potentially increasing ARF6 expression as part of broader effects on cellular function and differentiation. | ||||||