AKR7A2 Activators
AKR7A2 activators belong to a distinct chemical class that primarily interacts with a specific enzyme known as AKR7A2, or aldo-keto reductase family 7 member A2. This enzyme plays a crucial role in the detoxification and metabolism of various endogenous and exogenous compounds within the human body. AKR7A2, also known as aflatoxin aldehyde reductase, is a member of the aldo-keto reductase (AKR) superfamily of enzymes. These enzymes are involved in the reduction of aldehydes and ketones, making them essential in the detoxification of various xenobiotics and the regulation of endogenous metabolic processes. AKR7A2 activators are small molecules or compounds that have been identified as capable of modulating the activity of this specific enzyme.
The activation of AKR7A2 by its activators can lead to a range of biochemical effects, including enhanced catalytic activity, altered substrate specificity, or changes in its cellular localization. This modulation of AKR7A2 activity can have significant implications in the metabolism and clearance of toxic compounds, including carcinogens and environmental toxins. Additionally, these activators might have applications in studying the physiological roles of AKR7A2 in normal cellular processes and its potential involvement in disease states. Understanding how AKR7A2 activators influence the enzyme's function can provide valuable insights into the broader field of enzymology and chemical biology, shedding light on the intricate mechanisms that govern detoxification pathways and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $612.00 | 4 | |
A potent carcinogen found in tobacco smoke and grilled foods, benzo[a]pyrene induces AKR7A2 expression as a defense mechanism against its harmful effects. | ||||||
Naphthalene | 91-20-3 | sc-215533 sc-215533A | 250 mg 5 g | $20.00 $37.00 | ||
A volatile organic compound found in cigarette smoke and industrial emissions, naphthalene can induce AKR7A2 to metabolize and detoxify it. | ||||||
3-Methylcholanthrene | 56-49-5 | sc-252030 sc-252030A | 100 mg 250 mg | $388.00 $831.00 | 2 | |
Another polycyclic aromatic hydrocarbon, 3-methylcholanthrene is known to upregulate AKR7A2 to aid in its metabolism and elimination. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
An antibiotic often used to treat tuberculosis and other bacterial infections, rifampicin can induce AKR7A2 expression, possibly to aid in the metabolism of the drug. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
A synthetic organosulfur compound, oltipraz is known to induce phase II detoxification enzymes, including AKR7A2, to protect against carcinogens. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound found in turmeric, curcumin has been shown to induce AKR7A2 expression, contributing to its anti-inflammatory and antioxidant properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Found in red wine and certain fruits, resveratrol can induce AKR7A2, potentially helping the body detoxify harmful substances. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid abundant in fruits and vegetables, quercetin can induce AKR7A2, contributing to its antioxidant and anti-inflammatory effects. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Found in cruciferous vegetables, indole-3-carbinol can upregulate AKR7A2, potentially aiding in the metabolism of carcinogens. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Present in broccoli and other cruciferous vegetables, sulforaphane induces AKR7A2 and other detoxification enzymes to protect against carcinogens. | ||||||