AKR1CL1 Activators
AKR1C1, also known as aldo-keto reductase family 1 member C1, is an enzyme that belongs to the aldo-keto reductase (AKR) superfamily, which plays a pivotal role in the metabolism of various endogenous and exogenous aldehydes and ketones. AKR1C1 activators are compounds that increase the enzymatic activity of AKR1C1. These activators can bind to the enzyme and induce conformational changes that stabilize the enzyme in an active form or enhance its affinity for substrates. The exact mechanism by which these activators enhance AKR1C1 activity can vary and may involve interactions at the enzyme's active site or allosteric sites-regions of the enzyme separate from the active site that can modulate enzyme function when bound by certain molecules.
The chemical class of AKR1C1 activators is diverse, including a range of small organic molecules that share the ability to modulate enzyme function. These molecules are characterized by their varied chemical structures, which can interact with the enzyme in different ways to increase its activity. The structural diversity of AKR1C1 activators reflects the flexibility of the enzyme's binding sites and the potential for different chemical scaffolds to induce an activating effect. The specificity and potency of these activators are determined by their molecular architecture, which influences how they interact with the enzyme. The affinity of a particular activator for AKR1C1 is also a key factor in its ability to enhance the enzyme's activity, with higher affinity compounds generally being more potent activators. Understanding the relationship between structure and function in these molecules is central to comprehending how they influence AKR1C1 activity at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP serves as a co-factor for many enzymatic processes. For AKR1CL1, the availability of ATP can indirectly enhance its activity by providing the necessary phosphate groups for phosphorylation events that can alter AKR1CL1's conformation and thus its activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc acts as a cofactor for many enzymes and can enhance their activity. In the case of AKR1CL1, zinc may stabilize the structure of the enzyme or act as a catalytic cofactor, thereby enhancing its activity. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium is a cofactor that is essential for the activity of many enzymes. For AKR1CL1, magnesium can bind to the enzyme's active site or allosteric sites, resulting in a conformational change that enhances enzyme activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a cofactor for reductases, NADH can donate electrons and enhance the reductase activity of AKR1CL1, leading to an increased catalytic function. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $114.00 $198.00 | ||
Similar to NADH, NADPH acts as a reducing agent and can enhance the activity of AKR1CL1 by donating electrons for the reduction reactions it catalyzes. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Glutathione can act as a co-substrate for AKR1CL1, participating in detoxification reactions, thus enhancing the overall functional activity of AKR1CL1. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
As a universal methyl donor, S-adenosylmethionine can donate methyl groups to AKR1CL1 substrates, potentially increasing the substrate affinity and enhancing the enzymatic activity of AKR1CL1. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 can interact with specific receptors that might be linked to a pathway involving AKR1CL1, potentially leading to the enhanced activity of the enzyme as part of a signaling cascade. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP, which can activate PKA. PKA may then phosphorylate AKR1CL1 or associated proteins, indirectly enhancing AKR1CL1 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As a PKC activator, PMA can lead to the phosphorylation of proteins in pathways associated with AKR1CL1, potentially enhancing the activity of the enzyme. | ||||||