Date published: 2026-5-13

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AdipoR2 Activators

AdipoR2 Activators belong to a distinctive chemical class renowned for their pivotal role in the activation of the AdipoR2 receptor. AdipoR2, a member of the adiponectin receptor family, is a transmembrane protein predominantly found in various tissues, including adipose tissue, skeletal muscle, and liver. The activation of AdipoR2 is crucial in modulating cellular responses related to energy homeostasis, glucose metabolism, and fatty acid oxidation. The chemical compounds classified as AdipoR2 Activators are characterized by their ability to interact specifically with the AdipoR2 receptor, initiating a cascade of intracellular events that culminate in diverse physiological responses. Structurally, AdipoR2 Activators exhibit a diverse range of chemical frameworks, encompassing both synthetic and naturally derived compounds. These molecules share a common feature: the capability to bind to the AdipoR2 receptor, often involving specific molecular recognition patterns and interactions. The binding of AdipoR2 Activators to the receptor triggers a conformational change in the receptor's structure, leading to the activation of downstream signaling pathways. These pathways often involve intricate intracellular cascades, including the activation of kinases, modulation of second messenger systems, and altered gene expression profiles. The diverse array of AdipoR2 Activators underscores the complexity of their interactions with the receptor and their potential to fine-tune cellular responses. Researchers continue to explore the structural nuances of AdipoR2 Activators in order to decipher the molecular mechanisms underlying their interaction with the AdipoR2 receptor. By unraveling these interactions, scientists aim to gain deeper insights into cellular metabolism and energy regulation, shedding light on the fundamental processes that govern metabolic homeostasis. The study of AdipoR2 Activators provides a unique avenue to better understand the intricate interplay between molecules and receptors in cellular signaling, offering insights into the broader landscape of molecular pharmacology and cellular biology.

Items 1 to 10 of 15 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide

924416-43-3sc-396658
sc-396658A
10 mg
50 mg
$112.00
$454.00
1
(0)

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide demonstrates a distinctive mechanism of action through its selective binding to AdipoR2, modulating adipocyte function. The compound's structural features facilitate specific hydrogen bonding and hydrophobic interactions, promoting receptor activation. Its dynamic solubility profile enhances bioavailability, while the compound's stability under physiological conditions supports sustained engagement with metabolic pathways, contributing to its regulatory effects on energy homeostasis.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol, a natural polyphenol found in grapes and red wine, has been shown to increase the expression of AdipoR2. It might exert its effects via activation of SIRT1, which is associated with improved insulin sensitivity and metabolic function.

Deoxyschizandrin

61281-38-7sc-278925
10 mg
$80.00
(1)

Deoxyschizandrin exhibits a unique affinity for adiponectin receptors, particularly AdipoR2, facilitating intricate signaling cascades that modulate metabolic processes. Its molecular structure allows for specific hydrogen bonding and hydrophobic interactions, enhancing receptor binding efficiency. The compound's dynamic conformation enables it to engage in rapid equilibrium with the receptor, influencing downstream pathways. Additionally, its lipophilic characteristics contribute to its distribution and interaction with cellular membranes, affecting bioavailability and activity.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, a component of turmeric, can upregulate AdipoR2 expression. Its anti-inflammatory and antioxidant properties might contribute to improved adiponectin signaling.

Berberine

2086-83-1sc-507337
250 mg
$92.00
1
(0)

Berberine, an isoquinoline alkaloid, has been linked with increased AdipoR2 expression. It's believed to modulate lipid metabolism and improve insulin resistance.

4-Chloro-6,7-bis-(2-methoxy-ethoxy)-quinazoline

183322-18-1sc-357724
sc-357724A
100 mg
250 mg
$131.00
$262.00
(0)

Quinazoladine-Q is a quinazoline-based compound that has demonstrated selectivity in inhibiting AdipoR2 over other related receptors. It has shown efficacy in animal models of metabolic syndrome.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin, a flavonoid found in various foods, may increase AdipoR2 levels. Its antioxidant properties can modulate inflammation and potentially enhance adiponectin signaling.

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$120.00
$326.00
$634.00
$947.00
$1259.00
38
(1)

Rosiglitazone is a thiazolidinedione that might upregulate AdipoR2 expression. It works as a PPAR-γ agonist, affecting adipocyte differentiation and insulin sensitivity.

Fenofibrate

49562-28-9sc-204751
5 g
$41.00
9
(1)

Fenofibrate, a lipid-lowering drug, can increase AdipoR2 expression. It's a PPAR-α agonist, which modulates lipid metabolism pathways.

Pyridoxine Hydrochloride

58-56-0sc-219674
10 mg
$42.00
(0)

Pyridoxine Hydrochloride is a pyridoxine derivative that acts as an allosteric inhibitor of AdipoRIt binds to a distinct site on the receptor and modulates its conformation, rendering it incapable of responding to adiponectin binding.