ADH8 Inhibitors
The chemical class of ADH8 inhibitors encompasses compounds designed to directly or indirectly modulate the activity of alcohol dehydrogenase 8 (ADH8), a pivotal enzyme in alcohol metabolism. Direct inhibitors, including 4-Methylpyrazole, Cyanamide, and Fomepizole, exert their effect by binding to the active site of ADH8, thereby obstructing the conversion of alcohol to aldehyde. This targeted inhibition presents a precise mechanism to control ADH8 activity, affording mastery over alcohol metabolism and its associated cellular repercussions. These direct inhibitors stand as integral components in the intricate regulatory machinery governing alcohol metabolism.
Indirect inhibitors, such as Dimethyl Sulfoxide (DMSO), N-Acetylcysteine (NAC), and Zinc Chloride (ZnCl2), operate by modulating ADH8 activity through alterations in cellular redox status and cofactor availability. For example, DMSO indirectly augments the efficacy of direct inhibitors by influencing cellular redox conditions, portraying a sophisticated interplay between chemical modulators and cellular processes. Calcium Chloride (CaCl2) and 2,2'-Dipyridyl contribute to ADH8 regulation by indirectly enhancing enzyme stability and chelating iron ions, respectively. These indirect modulators offer additional dimensions to the regulation of ADH8 activity, impacting enzyme stability and cofactor availability. Dicoumarol, an inhibitor of NAD(P)H: quinone oxidoreductase, employs redox mechanisms to indirectly modulate ADH8, unveiling a distinctive approach to the intricate orchestration of alcohol metabolism. Metabolites such as Acetaldehyde and dietary compounds like Quercetin act as indirect inhibitors, serving as competitive inhibitors and redox modulators, respectively, to influence ADH8 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyanamide | 420-04-2 | sc-239592 sc-239592A | 5 g 25 g | $21.00 $77.00 | ||
Cyanamide, a competitive ADH inhibitor, directly interferes with the substrate-binding site of ADH8, hindering the conversion of alcohol to aldehyde. This direct inhibition disrupts the enzymatic activity of ADH8, providing a specific means to regulate alcohol metabolism. By competitively binding to ADH8, Cyanamide alters the enzyme's functionality, presenting a targeted approach for modulating ADH8 activity and influencing downstream cellular processes associated with alcohol metabolism. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $74.00 | 1 | |
Fomepizole, a potent ADH inhibitor, directly targets ADH8 by binding to its active site, inhibiting the conversion of alcohol to aldehyde. This direct inhibition disrupts the catalytic activity of ADH8, offering a specific means to regulate alcohol metabolism. By preventing the enzymatic conversion, Fomepizole serves as a targeted chemical inhibitor, influencing ADH8 activity and impacting cellular processes associated with alcohol metabolism in a controlled manner. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Dimethyl Sulfoxide (DMSO), an ADH modulator, indirectly influences ADH8 activity by altering cellular redox status. Acting as a solvent, it enhances the cellular penetration of other ADH inhibitors, amplifying their inhibitory effects on ADH8. This indirect modulation amplifies the impact of specific ADH inhibitors, offering a strategy to potentiate their effectiveness in regulating alcohol metabolism and associated cellular processes. Dimethyl Sulfoxide serves as an indirect modulator that can enhance the efficacy of other ADH inhibitors in a controlled and targeted manner. | ||||||
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $45.00 | ||
1-Octanol, an alcohol substrate, indirectly influences ADH8 by serving as a competitive substrate for the enzyme. By competing with endogenous alcohols, it can modulate the activity of ADH8, altering the conversion of alcohols to aldehydes. This indirect modulation provides a unique means to influence ADH8 activity, offering a controlled approach to regulating alcohol metabolism and related cellular processes. 1-Octanol acts as an indirect modulator by affecting the availability of substrates for ADH8, thereby influencing the enzyme's catalytic activity in a specific and controlled manner. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine (NAC), a redox modulator, indirectly influences ADH8 by altering cellular redox status. By serving as a precursor for glutathione synthesis, it enhances cellular antioxidant capacity, indirectly impacting ADH8 activity. This indirect modulation provides a means to regulate alcohol metabolism by influencing the redox environment of the cell. N-Acetylcysteine acts as an indirect modulator that can modulate ADH8 activity through redox mechanisms, offering a controlled approach to influencing alcohol metabolism and associated cellular processes in response to changes in cellular redox status. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Chloride (ZnCl2), a cofactor modulator, indirectly influences ADH8 by altering the availability of cofactors required for enzyme activity. By affecting zinc ion levels, it can modulate the catalytic efficiency of ADH8, impacting alcohol metabolism. This indirect modulation provides a means to regulate ADH8 activity by influencing the availability of essential cofactors. Zinc Chloride acts as an indirect modulator that can alter the activity of ADH8 through changes in cofactor availability, offering a controlled approach to influencing alcohol metabolism and associated cellular processes dependent on ADH8 catalysis. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium Chloride (CaCl2), an enzyme stabilizer, indirectly influences ADH8 by enhancing enzyme stability. By stabilizing the conformation of ADH8, it can indirectly modulate the enzyme's catalytic activity, impacting alcohol metabolism. This indirect modulation provides a means to regulate ADH8 activity by influencing enzyme stability. Calcium Chloride acts as an indirect modulator that can enhance the stability of ADH8, offering a controlled approach to influencing alcohol metabolism and associated cellular processes dependent on ADH8 catalysis. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $39.00 | 8 | |
quinone oxidoreductase, indirectly influences ADH8 by altering the cellular redox status. By inhibiting the regeneration of NADH, it indirectly modulates ADH8 activity, impacting alcohol metabolism. This indirect modulation provides a means to regulate ADH8 activity by influencing the redox environment of the cell. Dicoumarol acts as an indirect modulator that can modulate ADH8 activity through redox mechanisms, offering a controlled approach to influencing alcohol metabolism and associated cellular processes in response to changes in cellular redox status. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, indirectly influences ADH8 by modulating cellular redox status. By acting as an antioxidant, it indirectly impacts ADH8 activity, potentially influencing alcohol metabolism. This indirect modulation provides a means to regulate ADH8 activity by influencing the redox environment of the cell. Quercetin acts as an indirect modulator that can modulate ADH8 activity through redox mechanisms, offering a controlled approach to influencing alcohol metabolism and associated cellular processes in response to changes in cellular redox status. | ||||||