Adducin β Inhibitors
The Adducin β Inhibitors represent a diverse group of chemicals that intricately modulate cellular processes by directly or indirectly influencing the activity of Adducin β. Calyculin A and Okadaic Acid stand out as direct inhibitors, targeting protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, both compounds disrupt the dephosphorylation of Adducin β, leading to increased phosphorylation levels and modulation of cellular processes associated with Adducin β functions.
In addition to direct inhibitors, several compounds, such as Jasplakinolide, Cytochalasin D, Blebbistatin, Latrunculin A, CK-666, SMIFH2, and NSC23766, exert their inhibitory effects indirectly by influencing actin dynamics. These compounds target various components of the actin cytoskeleton, including actin polymerization inhibitors (Jasplakinolide, Cytochalasin D, Latrunculin A), myosin II ATPase inhibitor (Blebbistatin), Arp2/3 complex inhibitors (CK-666, SMIFH2, CK-869), and Rac1-GEF interaction inhibitor (NSC23766). Through these mechanisms, these compounds alter the organization and dynamics of the actin cytoskeleton, influencing the interactions of Adducin β with actin filaments and resulting in the modulation of cellular processes associated with Adducin β functions. Calyculin A and Okadaic Acid, as direct inhibitors, highlight the importance of precise phosphorylation dynamics in Adducin β regulation, while the indirect inhibitors showcase the intricate relationship between actin cytoskeleton dynamics and Adducin β function. These chemicals collectively serve as valuable tools for researchers studying the complex regulatory networks involving Adducin β, contributing to a deeper understanding of the molecular mechanisms governing cellular processes associated with Adducin β functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases, specifically PP1 and PP2A. By inhibiting these phosphatases, Calyculin A disrupts the dephosphorylation of proteins, leading to increased phosphorylation levels of targets, including Adducin β. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is another potent inhibitor of protein phosphatases, primarily PP1 and PP2A. Similar to Calyculin A, Okadaic Acid disrupts dephosphorylation processes, leading to increased phosphorylation of Adducin β and modulation of cellular processes associated with its functions. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide, a natural product, indirectly inhibits Adducin β by disrupting actin dynamics. By stabilizing F-actin, Jasplakinolide alters the actin cytoskeleton, affecting the interaction of Adducin β with actin filaments. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is a fungal metabolite that indirectly inhibits Adducin β by disrupting actin polymerization. Through its impact on actin filaments, Cytochalasin D influences the organization of the actin cytoskeleton, leading to altered interactions with Adducin β. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a selective inhibitor of myosin II, indirectly influencing Adducin β by affecting actin-myosin interactions. By inhibiting myosin II ATPase activity, Blebbistatin disrupts the contractility of actin filaments, influencing the dynamics of the actin cytoskeleton and its interactions with Adducin β. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, a toxin found in marine sponges, indirectly inhibits Adducin β by disrupting actin polymerization. Through its sequestration of monomeric actin, Latrunculin A prevents actin filament assembly, influencing the organization of the actin cytoskeleton and its interactions with Adducin β. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is a specific inhibitor of the Arp2/3 complex, indirectly inhibiting Adducin β by affecting actin polymerization. By targeting the Arp2/3 complex, CK-666 disrupts the nucleation of actin filaments, influencing the dynamics of the actin cytoskeleton and its interactions with Adducin β. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is another inhibitor of the Arp2/3 complex, indirectly influencing Adducin β by affecting actin polymerization. Similar to CK-666, SMIFH2 disrupts the nucleation of actin filaments through inhibition of the Arp2/3 complex, altering the dynamics of the actin cytoskeleton and its interactions with Adducin β. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC23766 is a specific inhibitor of the Rac1-GEF interaction, indirectly inhibiting Adducin β by affecting actin dynamics. By disrupting Rac1 activation, NSC23766 influences the organization of the actin cytoskeleton, leading to altered interactions with Adducin β. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is a selective inhibitor of the Arp2/3 complex, indirectly influencing Adducin β by affecting actin polymerization. Similar to CK-666, CK-869 disrupts the nucleation of actin filaments through inhibition of the Arp2/3 complex, altering the dynamics of the actin cytoskeleton and its interactions with Adducin β. | ||||||