ADAT1 Inhibitors

The ADAT1 Inhibitors principally target broader cellular processes and pathways that revolve around tRNA, its modification, and the general machinery of protein translation. While the direct inhibition of ADAT1 remains elusive, targeting processes adjacent to ADAT1's function may present opportunities to indirectly modulate its activity.

Halofuginone and Mimosine, for instance, are inhibitors of aminoacyl-tRNA synthetases. By affecting tRNA aminoacylation, there's the to indirectly impact tRNA modifications done by enzymes like ADAT1. Compounds like Cordycepin and Ribavirin, being analogues of nucleosides, have the to influence pathways related to tRNA modifications. Their incorporation into RNA might affect the substrate availability or recognition by enzymes like ADAT1. The intricate balance in the protein translation machinery, encompassing enzymes responsible for tRNA modifications, suggests that perturbations in this equilibrium can have cascading effects. Puromycin and Cycloheximide, known to disrupt protein translation, could indirectly affect tRNA modification enzymes as changes in the translation process might change the demand for specific tRNA modifications.