ADAM33 Activators
ADAM33 Activators are a unique class of chemicals that have the ability to enhance the functional activity of ADAM33, a protein implicated in various cellular processes. This enhancement comes as a result of these activators exerting influence on specific signaling pathways or biological processes that ADAM33 is directly involved in. For instance, SB-431542 and A-83-01 indirectly enhance ADAM33 activity by inhibiting the negative feedback of the TGF-β signaling pathway, a pathway that ADAM33 potentially participates in. Similarly, the proteasome inhibitor MG-132 increases the availability of the ADAM33 protein, thus indirectly enhancing its activity.
Forskolin, an activator of adenylyl cyclase, can indirectly enhance ADAM33 activity by increasing cAMP levels and therefore affecting various signaling pathwaysthat ADAM33 is part of. Moreover, SP600125 and PD0325901, inhibitors of JNK and MEK respectively, can increase the demand for ADAM33's proteolytic and sheddase functions, thus indirectly enhancing its activity. Furthermore, chemicals like BAY 11-7082 and QNZ suppress the activation of NF-κB, indirectly enhancing ADAM33 activity due to the protein's potential role in NF-κB signaling. Lastly, BAPTA-AM, a calcium chelator, could enhance the activity of ADAM33 by influencing calcium signaling, another pathway ADAM33 may be involved in.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is a selective inhibitor of the TGF-β type I receptor activin receptor-like kinase (ALK). TGF-β signaling is a potential pathway that ADAM33 is involved in. By inhibiting the negative feedback of this pathway, SB-431542 could indirectly enhance the activity of ADAM33. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor. JNK is involved in various cellular processes that ADAM33 could be part of. By inhibiting JNK, SP600125 could enhance ADAM33 activity by increasing the demand for its proteolytic functions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, a kinase involved in the regulation of smooth muscle contraction, a process where ADAM33 could play a role. By inhibiting ROCK, Y-27632 could indirectly enhance ADAM33 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents protein degradation. As ADAM33 is a protein, MG-132 could enhance its activity by increasing its availability. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation. NF-κB signaling is involved in inflammation, a process where ADAM33 could play a role. By inhibiting NF-κB, BAY 11-7082 could indirectly enhance the activity of ADAM33. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling is a potential pathway that ADAM33 is involved in. By inhibiting PI3K, LY294002 could indirectly enhance the activity of ADAM33. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, leading to increased cAMP levels. cAMP is involved in various signaling pathways that ADAM33 could be part of. Increased cAMP levels could indirectly enhance ADAM33 activity. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A-83-01 is a selective inhibitor of TGF-β type I receptor ALK. Similar to SB-431542, by inhibiting the negative feedback of TGF-β signaling, A-83-01 could indirectly enhance the activity of ADAM33. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $117.00 | 12 | |
QNZ suppresses the activation of NF-κB. By inhibiting NF-κB, QNZ could indirectly enhance the activity of ADAM33, similar to BAY 11-7082. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator. Calcium signaling is a potential pathway that ADAM33 is involved in. By chelating calcium, BAPTA-AM could indirectly enhance the activity of ADAM33. | ||||||