ACTR10 Inhibitors
ACTR10 inhibitors encompass a variety of compounds that directly or indirectly affect the functional activity of ACTR10 by targeting the actin cytoskeleton dynamics and associated regulatory proteins. For instance, certain inhibitors bind to actin monomers or filaments, impeding their polymerization or stabilization, thus obstructing the formation of the intricate actin structures essential for a range of cellular functions. These inhibitors, by either blocking the polymerization and elongation of actin filaments, severing existing filaments, or stabilizing them beyond their functional capacity, inhibit ACTR10's ability to engage in the assembly and maintenance of the cytoskeleton. Others operate by binding to actin and preventing its polymerization, thereby directly disrupting the cytoskeletal infrastructure critical to ACTR10-mediated processes.
Moreover, some inhibitors target regulatory molecules such as myosin light chain kinase or Rho-associated protein kinase, which are key to actin filament interaction and organization. By impeding the action of these kinases, the inhibitors indirectly influence ACTR10's role in actin-mediated cellular activities. Additional inhibitors act upon the Arp2/3 complex and formin homology 2 domains, which are involved in actin nucleation and elongation, subsequently altering actin dynamics and potentially affecting ACTR10's involvement in these processes. The inhibition of neuronal Wiskott-Aldrich syndrome protein, which is instrumental in actin polymerization, further exemplifies this indirect approach to impeding ACTR10's functional repertoire.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
This compound binds to actin monomers, preventing their polymerization. As ACTR10 is an actin-related protein, Latrunculin A inhibits the formation of actin filaments, thereby affecting ACTR10's ability to function in actin cytoskeleton dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
This alkaloid binds to the barbed ends of actin filaments, blocking polymerization and elongation. This directly impacts ACTR10's role in the assembly and maintenance of the cytoskeleton. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
A bis-lactone macrolide that severs actin filaments and prevents their reannealing. This disrupts the actin cytoskeleton structure and function, indirectly inhibiting ACTR10 activity. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
A cyclic peptide that stabilizes actin filaments and prevents their depolymerization. By stabilizing filaments, it potentially alters the dynamics required for ACTR10's normal function within the actin cytoskeleton. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
It tightly binds to F-actin, stabilizing the filaments and inhibiting their disassembly, which can indirectly affect the function of ACTR10 in regulating actin dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
An inhibitor of myosin light chain kinase (MLCK), which plays a role in the phosphorylation of myosin and actin interactions. Inhibition of MLCK can alter actin dynamics, thus indirectly affecting ACTR10's function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of ROCK (Rho-associated protein kinase), which is involved in actin cytoskeleton organization. Inhibition of ROCK can lead to changes in actin filament organization and thus impact ACTR10 function. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
An inhibitor of the Arp2/3 complex, which nucleates new actin filaments. By inhibiting this complex, CK 666 disrupts actin branching and network formation, indirectly affecting ACTR10's activity related to actin polymerization. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
A small molecule inhibitor of formin homology 2 (FH2) domains in formins that nucleate and elongate unbranched actin filaments, thereby affecting ACTR10's involvement in the regulation of actin filament formation and organization. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
An inhibitor of myosin II ATPase activity, which can affect muscle contraction and cell motility by altering actin-myosin dynamics. This can indirectly inhibit the function of ACTR10 in actin filament-based processes. | ||||||