Activin Activators
Activin is a complex protein that plays a vital role in many biological processes. It belongs to the transforming growth factor-beta (TGF-β) superfamily, a group of proteins known for their extensive involvement in cellular functions such as cell growth, differentiation, and apoptosis. Predominantly recognized for its function in embryogenesis and tissue repair in adults, Activin is a dimeric protein, usually composed of two identical or very similar beta subunits, often referred to as inhibin beta. This protein is implicated in a variety of important biological functions including metabolism, homeostasis, immune response, wound healing, and endocrine function. Its expression can be responsive to numerous stimuli, providing a dynamic and adaptive component to cellular and organismal physiology.
The expression of Activin can be influenced by various chemical compounds, each having the potential to interact with cellular systems in a unique way to promote its production. For instance, Retinoic Acid and Vitamin D3 are known to interact with nuclear receptors, instigating a chain of events that can enhance the expression of Activin. Similarly, hormones like Estradiol, Progesterone, and Testosterone can bind to their respective receptors and may stimulate the transcription of Activin. Certain compounds like Dexamethasone and Insulin can also bind to their specific receptors, initiating a signaling cascade that may lead to an increase in Activin expression. Additionally, compounds like Forskolin, Lithium Chloride, Sodium Butyrate, Epigallocatechin Gallate (EGCG), and Resveratrol have been shown to alter various cellular processes and pathways and may promote the expression of Activin. Each of these compounds illustrates the diverse array of chemical activators that can potentially induce the expression of this multifunctional protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid serves as a ligand for nuclear receptors, stimulating a cascade of events that can upregulate the expression of activin. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 (Cholecalciferol), through its active metabolite Calcitriol, can enhance the transcription of genes like activin, by binding to the vitamin D response elements (VDREs) in their promoter regions. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol can bind to the estrogen receptor, triggering a series of events that promote the transcription and subsequent expression of certain genes, possibly including activin. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone can bind to progesterone receptors, triggering a chain of events that may stimulate the transcription and subsequent expression of genes, including activin. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, can bind to glucocorticoid receptors, initiating a cascade of events that may enhance the transcription and subsequent elevated expression of genes, such as activin. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin, by activating the insulin receptor, can trigger a signaling cascade that may stimulate the transcription of certain genes, including activin, leading to their increased expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, by increasing intracellular cyclic AMP levels, may stimulate a series of cellular events leading to the enhanced transcription and subsequent expression of genes, potentially including activin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit the activity of glycogen synthase kinase-3 beta (GSK-3β), which may lead to an altered transcription landscape, possibly promoting the expression of activin. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, can inhibit histone deacetylases, altering chromatin structure and potentially promoting the transcription and subsequent expression of genes, such as activin. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a polyphenol found in green tea, can inhibit certain kinases and other proteins, potentially leading to the increased transcription and subsequent expression of genes, like activin. | ||||||