ACRC Activators
ACRC Activators are a group of chemical compounds that work to enhance the functional activity of ACRC, a protein involved in assorted cellular processes. These activators function by either modulating the post-translational modifications of ACRC or activating the signaling pathways that ACRC is a part of. Notably, ATP enhances ACRC's chaperone activity by providing more substrate availability. Forskolin and 8-Bromo-cAMP work by activating protein kinases which can phosphorylate and activate ACRC. MG-132, a proteasome inhibitor, prevents the degradation of phosphorylated ACRC, thus enhancing its activity.
Other ACRC activators, such as PMA, EGF, and Insulin, function by activating protein kinases or signaling pathways that can phosphorylate and activate ACRC. U0126 is an inhibitor that suppresses pathways or enzymes that would typically inhibit ACRC. This suppression indirectly enhances the activation of ACRC. Lastly, BAPTA-AM, a calcium chelator, enhances ACRC activity by inhibiting a phosphatase that dephosphorylates ACRC, thereby maintaining the phosphorylation status and the activity of ACRC.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP provides the energy required for ACRC to facilitate its chaperone activity. An increase in ATP concentration can enhance ACRC's activity by providing a higher substrate availability. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can phosphorylate and activate ACRC, which can enhance the activity of ACRC by promoting its interaction with client proteins. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, increasing the levels of cyclic AMP (cAMP). Elevated cAMP levels can activate protein kinase A (PKA), which can phosphorylate and activate ACRC, thus enhancing its chaperone activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that can activate PKA. PKA can phosphorylate and activate ACRC, thereby enhancing its chaperone activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of phosphorylated proteins. By preventing the degradation of phosphorylated ACRC, MG-132 can enhance the activity of ACRC. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, leading to activation of the PI3K/AKT pathway. ACRC is a known downstream effector of this pathway, so activation of this pathway can enhance the activity of ACRC. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that can decrease intracellular calcium levels. Reduced calcium levels can inhibit calcineurin, a phosphatase that dephosphorylates ACRC, thereby maintaining the phosphorylation status and activity of ACRC. | ||||||