ACK Activators
ACK Activators belong to a chemical class of compounds that are involved in the modulation of the activity of ACK, which stands for "Activated Cdc42 kinase." ACK is a member of the non-receptor tyrosine kinase family and plays a significant role in regulating various cellular processes, particularly those related to cell signaling, cytoskeletal dynamics, and cell adhesion. The kinase activity of ACK is primarily directed towards the phosphorylation of specific tyrosine residues on target proteins, thereby influencing their functions. ACK Activators are small molecules designed to interact with ACK, altering its kinase activity and, subsequently, the downstream signaling events and cellular responses that it regulates.
The mechanism of action of ACK Activators typically involves binding to specific regions of the ACK enzyme, leading to conformational changes that can either enhance or inhibit its kinase activity. By modulating ACK activity, these activators can impact cellular processes such as actin cytoskeleton remodeling, cell migration, and the regulation of cell adhesion molecules. ACK Activators have gained importance as valuable tools in cellular and molecular biology research, providing insights into the complex regulatory networks governing cell behavior. Their study helps elucidate the roles of ACK in various physiological and pathological contexts, offering a deeper understanding of the intricate signaling pathways and cellular functions that are regulated by this kinase.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family kinases. By inhibiting Src kinases, PP2 may cause compensatory cellular responses that indirectly activate TNK2. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
Saracatinib is a Src inhibitor. Its inhibition of Src kinases, which are closely related to TNK2, might result in altered signaling pathways that indirectly activate TNK2. | ||||||
PF-562271 | 717907-75-0 | sc-478488 sc-478488A sc-478488B | 5 mg 10 mg 50 mg | $312.00 $474.00 $1124.00 | 3 | |
PF-562271 is a dual inhibitor of FAK and Pyk2, kinases that are part of signaling pathways overlapping with TNK2. Its use might indirectly affect TNK2 activity. | ||||||
AP 24534 | 943319-70-8 | sc-362710 sc-362710A | 10 mg 50 mg | $175.00 $983.00 | 2 | |
AP 24534 is a multi-target kinase inhibitor that, while primarily targeting BCR-ABL, also affects Src family kinases, potentially influencing TNK2 activity. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $87.00 $135.00 $293.00 $505.00 $3827.00 | 42 | |
Erlotinib is an EGFR inhibitor. Given the interconnected nature of kinase signaling pathways, it might affect TNK2 activity. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib inhibits EGFR, a protein involved in numerous signaling pathways that could intersect with TNK2 activation mechanisms. | ||||||