Date published: 2025-9-18

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ACE Inhibitors

ACE inhibitors, or angiotensin-converting enzyme inhibitors, constitute a distinct class of chemical compounds that interact with the angiotensin-converting enzyme within the renin-angiotensin-aldosterone system (RAAS). This enzyme is integral to the regulation of blood pressure and fluid balance. ACE inhibitors play a pivotal role in modulating the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor and stimulator of aldosterone secretion. By targeting the ACE enzyme, these inhibitors influence the downstream effects of the RAAS, which include controlling blood vessel constriction and fluid retention. The function of ACE inhibitors involves their meticulous interaction with the active site of the ACE enzyme, obstructing its ability to convert angiotensin I to angiotensin II. This, in turn, leads to vasodilation and a reduction in the release of aldosterone. The pharmacological effects of ACE inhibitors are underpinned by their role in attenuating the constriction of blood vessels and promoting the excretion of sodium and water from the body. This class of inhibitors has garnered significant attention for its ability to impact cardiovascular health and blood pressure regulation. By virtue of their mechanism of action, ACE inhibitors contribute to a broader understanding of the intricate interplay between hormonal signaling pathways that govern blood pressure, fluid balance, and overall cardiovascular function.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

TAPI-2

187034-31-7sc-205851
sc-205851A
1 mg
5 mg
$280.00
$999.00
15
(1)

TAPI-2, as an acid chloride, exhibits exceptional reactivity attributed to its highly electrophilic carbonyl center, which promotes swift nucleophilic attack. This compound's unique steric and electronic properties allow for selective acylation, enabling the formation of various derivatives. Its halogen substituents not only enhance reactivity but also influence reaction kinetics, making TAPI-2 a versatile intermediate in complex synthetic routes, facilitating intricate molecular transformations.

Captopril

62571-86-2sc-200566
sc-200566A
1 g
5 g
$48.00
$89.00
21
(1)

Captopril inhibits ACE, reducing angiotensin II levels and promoting vasodilation, resulting in lower blood pressure and improved cardiac function.

Perindoprilat

95153-31-4sc-208160
sc-208160A
sc-208160A-CW
5 mg
10 mg
10 mg
$398.00
$653.00
$826.00
4
(0)

Perindopril inhibits ACE, leading to reduced angiotensin II levels, vasodilation, and lower blood pressure, benefiting patients with hypertension and heart failure.

Lisinopril

76547-98-3sc-205378
sc-205378A
100 mg
500 mg
$20.00
$40.00
2
(1)

Lisinopril is an ACE inhibitor that prevents the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion, leading to vasodilation and lower blood pressure.

Enalapril

75847-73-3sc-205664
sc-205664A
sc-205664B
100 mg
5 g
1 g
$159.00
$2556.00
$669.00
3
(2)

Enalapril is a prodrug that inhibits ACE, preventing angiotensin II formation and reducing blood pressure by vasodilation and decreased aldosterone release.

Trandolapril

87679-37-6sc-203299
sc-203299A
10 mg
50 mg
$105.00
$420.00
(0)

Trandolapril inhibits ACE, reducing angiotensin II levels, promoting vasodilation, and leading to lower blood pressure and improved cardiovascular outcomes.

Benazepril-d5

1279200-03-1sc-217708
1 mg
$367.00
(0)

Benazepril inhibits ACE, reducing angiotensin II levels, promoting vasodilation, and leading to lower blood pressure and improved cardiovascular outcomes.

(1R) Perindopril-d4

sc-213634
1 mg
$430.00
(0)

(1R) Perindopril-d4, as an ACE inhibitor, features a deuterated structure that alters its isotopic composition, impacting its metabolic pathways and stability. The presence of deuterium enhances the compound's resistance to enzymatic degradation, allowing for prolonged activity in biochemical environments. Its unique molecular interactions, particularly with zinc ions in the active site of ACE, facilitate selective binding, influencing the kinetics of angiotensin II formation and modulation of blood pressure regulation.

Quinapril-d5, Hydrochloride

1356020-03-5sc-219686
1 mg
$330.00
(0)

Quinapril-d5, Hydrochloride, is a deuterated derivative that exhibits unique isotopic labeling, which influences its reactivity and interaction dynamics. The incorporation of deuterium enhances its stability and alters its kinetic profile, allowing for distinct metabolic pathways. Its specific interactions with the active site of angiotensin-converting enzyme (ACE) promote selective inhibition, affecting the enzyme's catalytic efficiency and modulating the formation of angiotensin II.

Ramipril

87333-19-5sc-205833
sc-205833A
sc-205833B
sc-205833C
sc-205833D
500 mg
1 g
2 g
5 g
10 g
$175.00
$240.00
$357.00
$719.00
$1229.00
1
(1)

Ramipril inhibits ACE, decreasing angiotensin II production and promoting vasodilation, which results in lower blood pressure and reduced cardiac workload.