Perindoprilat CAS: 95153-31-4
MF: C17H28N2O5
MW: 340.41
An angiotensin-converting enzyme (ACE) inhibitor.

Perindoprilat (CAS 95153-31-4)

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备用名: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; [2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; S 9780; USP Perindopril Related Compound B
应用; Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor
CAS号码: 95153-31-4
分子量: 340.41
分子式: C17H28N2O5
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Perindoprilat is an active metabolite of Perindopril (sc-205799), an ACE (angiotensin converting enzyme) inhibitor, which modulates the activity of low density lipoprotein receptor-related protein (LRP). LRP is a multifunctional endocytic receptor, which functions in the turnover of proteases and the degradation of extracellular matrix proteins. It is known that Perindoprilat inhibits the conversion of angiotensin I into angiotensin II, which lowers arteriolar pressure and increases venous capacity.


参考文献

1. Bree, F., et al. 1992. Int J Clin Pharmacol Ther Toxicol. 30: 325-330. PMID: 1330941
2. Pawluczyk, I.Z., et al. 2008. J. Biol. Chem. 283: 4588-4594. PMID: 18156630

物理状态 :
Solid
溶解度 :
Soluble in ethanol, methanol, and water.
保存 :
Store at -20° C
熔点 :
136-140° C
沸点 :
~568.1° C at 760 mmHg (Predicted)
密度 :
~1.2 g/cm3 (Predicted)
折射率 :
n20D 1.54 (Predicted)
pK值 :
pKa: 2.27 (Predicted), pKb: 8.13 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
ND6007250
PubChem CID :
MDL 号码 :
MFCD00865777
SMILES :

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