ACBD5 Inhibitors
ACBD5 inhibitors are chemical compounds that can indirectly influence the function of ACBD5, a protein involved in very long-chain fatty acid metabolism and localized in the peroxisome membrane. For instance, inhibitors like Bafilomycin A1, U18666A, and Methyl β-cyclodextrin can disrupt cellular pH homeostasis, cholesterol balance, and lipid raft dynamics, respectively, which are essential for the normal function of membrane proteins like ACBD5. Similarly, compounds like Trifluoperazine and 2-Bromopalmitate can interfere with protein-protein interactions and post-translational modifications, affecting the interaction of ACBD5 with PEX19 and its proper localization.
In addition, inhibitors that affect intracellular trafficking and cytoskeletal dynamics can influence the localization and function of ACBD5. For instance, Nocodazole and Latrunculin B, which disruptmicrotubules and microfilaments respectively, can interfere with transport processes and organelle shape maintenance, crucial for peroxisome function and ACBD5 activity. Similarly, inhibitors of endocytic and exocytic pathways, such as Brefeldin A and Dynasore, can disrupt the transport of proteins, impacting ACBD5. Phosphatidylinositol, an important player in cellular signaling and membrane trafficking, can also disrupt the normal localization and function of ACBD5. In the context of actin dynamics, Wiskostatin, an inhibitor of the neural Wiskott-Aldrich syndrome protein, can also impact the functional activity of ACBD5.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $57.00 $101.00 | 9 | |
Trifluoperazine is a calmodulin inhibitor. ACBD5 interacts with PEX19, a protein essential for peroxisomal biogenesis, through its PEX19-binding site. Calmodulin inhibitors can interfere with the binding of ACBD5 to PEX19, indirectly leading to a decrease in the functional activity of ACBD5. | ||||||
2-Bromohexadecanoic acid | 18263-25-7 | sc-251714 sc-251714A | 10 g 50 g | $53.00 $201.00 | 4 | |
2-Bromopalmitate is a palmitoylation inhibitor, and palmitoylation is a key process in protein trafficking and localization. By inhibiting palmitoylation, 2-Bromopalmitate can disrupt the normal localization and function of ACBD5. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $53.00 $620.00 $1989.00 $133.00 | 8 | |
Methyl β-cyclodextrin is known to disrupt lipid rafts by depleting cholesterol from cell membranes. As ACBD5 is a membrane protein, alterations in the lipid environment can affect its localization and function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin B is a compound that disrupts microfilaments, which play a role in cellular processes such as transport and maintenance of organelle shape. Disruption of microfilaments can affect the proper function and localization of ACBD5. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase. It can interfere with intracellular transport and pH homeostasis, which can indirectly affect the function of membrane proteins like ACBD5. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore acts as a non-competitive inhibitor of the GTPase activity of Dynamin, which plays a significant role in membrane fission during endocytosis. Inhibition of Dynamin can disrupt the endocytic pathway and potentially impact the functional activity of ACBD5. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an inhibitor of the neural Wiskott-Aldrich syndrome protein (N-WASP), a key regulator of actin polymerization. Disruption of actin dynamics can influence the localization and function of membrane proteins like ACBD5. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that can affect intracellular transport and organelle distribution. This may indirectly influence the function and localization of ACBD5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). PI3K is involved in many cellular processes, including intracellular trafficking. Therefore, inhibition of PI3K can impact the function of ACBD5. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a drug that inhibits the transport of protein from the endoplasmic reticulum to the Golgi apparatus. It can disrupt the normal cellular trafficking processes, potentially affecting the localization and function of ACBD5. | ||||||