ABLIM1 Activators
ABLIM1 activators encompass a diverse range of chemicals that engage in various cellular signaling pathways, ultimately leading to the functional activation of this actin-binding protein. One class of activators works by increasing intracellular second messenger levels, such as cAMP, which then activates protein kinases responsible for phosphorylating ABLIM1, enhancing its ability to interact with the actin cytoskeleton. Another set of activators targets phosphatase inhibition, which sustains the phosphorylation state of ABLIM1, thereby maintaining its high-affinity binding to actin fibers and its participation in cytoskeletal rearrangements. Additionally, some activators induce actin stabilization, which could amplify ABLIM1's engagement with actin filaments, integral to cellular structure and intracellular transport.
Furthermore, activators that disrupt the dynamic equilibrium of actin polymerization and depolymerization can indirectly provoke a cellular response that increases ABLIM1 activity to compensate for changes in actin architecture. Such chemical agents may cause a cellular feedback mechanism that leads to the enhanced role of ABLIM1 in stabilizing actin filaments. Other compounds exert their effects by modulating the activity of kinases and phosphatases that are critical in actin-myosin contractility and actin filament turnover.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, leading to an increase in cAMP levels which can enhance ABLIM1’s role in actin dynamics by cAMP-dependent protein kinase (PKA) phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which may phosphorylate ABLIM1, modulating its interaction with actin and influencing actin cytoskeleton rearrangements. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, preventing dephosphorylation and thus potentially maintaining ABLIM1 in an active phosphorylated state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibitor of protein phosphatases PP1 and PP2A like Calyculin A, which may sustain ABLIM1 phosphorylation and its associated actin binding activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Engages insulin receptor signaling leading to actin cytoskeletal changes; ABLIM1, as an actin-binding protein, may be activated in response to such changes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences glycogen synthase kinase 3 (GSK-3) activity, which is involved in actin organization; ABLIM1 would be activated as it participates in actin cytoskeleton regulation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin polymerization, which may lead to compensatory mechanisms activating ABLIM1 to stabilize actin filaments. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and prevents their disassembly; ABLIM1, being an actin-binding protein, may have enhanced activity in the presence of stabilized actin. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibitor of the actin depolymerizing factor/cofilin pathway, potentially leading to increased actin filament stability and activation of ABLIM1’s binding to actin. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibitor of myosin light chain kinase (MLCK), affects actin-myosin contractility; ABLIM1 may be activated as part of the cellular response to altered contractility. | ||||||