ABCD1 Activators
ABCD1 Activators are a distinctive class of chemical compounds that play a significant role in modulating the activity of the protein ABCD1, which is encoded by the gene ABCD1. These activators are specifically tailored to enhance the function of ABCD1 through a variety of cellular mechanisms and biochemical pathways. For instance, certain phospholipids that mimic the natural ligands of ABCD1 can insert themselves into the lipid bilayer of peroxisomal membranes, leading to a conformational change in the protein that boosts its activity. The enhanced function of ABCD1 is crucial for the transport of very long-chain fatty acids (VLCFAs) across the peroxisomal membrane, a process indispensable for proper peroxisomal beta-oxidation. Other activators in this class include small molecules that increase the affinity of ABCD1 for its substrates, thereby accelerating the rate of VLCFA transport. By stabilizing the active form of ABCD1, these molecules ensure that the protein operates at peak efficiency, which is essential for maintaining cellular homeostasis and normal metabolic function.
In addition to substrate affinity modulators, the ABCD1 Activators class also encompasses compounds that enhance the protein's expression through indirect pathways. These compounds may function by stabilizing ABCD1 mRNA, leading to an increase in protein synthesis, or by modulating the signaling pathways that govern the expression of the ABCD1 gene. For example, certain fatty acid derivatives can activate nuclear receptors that, in turn, bind to the promoter region of the ABCD1 gene, upregulating its expression. This upregulation results in a higher concentration of ABCD1 protein in the peroxisomes, subsequently improving the efficiency of VLCFA transport and metabolism. The unique mechanisms of action exhibited by each member of the ABCD1 Activators class underscore their importance in the precise regulation of ABCD1, ensuring that the protein's activity is optimized without directly altering its transcription or translation processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and enhance the activity of ABCD1 by promoting its translocation or changing its conformation for better substrate interaction. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased levels of cAMP and cGMP by preventing their degradation. The subsequent activation of PKA can phosphorylate ABCD1, enhancing its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which can deacetylate proteins and affect their function. Through this action, SIRT1 activation could lead to the deacetylation of ABCD1, potentially enhancing its activity or stability. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to the activation of several downstream proteins. If ABCD1 is a substrate or is regulated by a protein downstream of GSK-3, its activity could be enhanced by lithium. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression through retinoic acid receptors. Although typically involved in gene transcription, it can also affect protein function post-translationally. If ABCD1 function is modulated by retinoic acid signaling, this could lead to its enhanced activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates the activity of various protein kinases. By inhibiting certain kinases that may keep ABCD1 in an inactive state, curcumin could lead to an indirect enhancement of ABCD1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits various protein kinases and has been shown to alter signaling pathways. By modulating kinases that control the phosphorylation state of ABCD1, EGCG could enhance its activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPARγ). If ABCD1 activity is linked to PPARγ signaling, pioglitazone could enhance the activity of ABCD1 through this pathway. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid 1 (TRPV1), which can lead to calcium influx. This increase in intracellular calcium may activate calcium-dependent kinases that could phosphorylate and activate ABCD1. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $352.00 $520.00 $775.00 $6640.00 | 2 | |
Oleuropein has antioxidant properties and can modulate kinase activity. By affecting the kinase signaling network, oleuropein might enhance the activity of ABCD1 by modulating kinases that interact with or modify ABCD1. | ||||||