9230110C19Rik Inhibitors
Chemical inhibitors of cilia and flagella associated protein 300 operate through various mechanisms to impede its function within ciliary and flagellar structures. Niclosamide can inhibit the Wnt/β-catenin signaling pathway, which is essential for the proper assembly of ciliary components, thereby affecting the functioning of cilia and flagella associated protein 300. Similarly, Roscovitine, by being a cyclin-dependent kinase inhibitor, can halt cell cycle progression that is vital for ciliogenesis, which in turn is crucial for the proper function of cilia and flagella associated protein 300. Cytochalasin D disrupts the organization of actin filaments, which are necessary for the structural integrity and movement of cilia. This disruption can lead to an inhibition of the functions typically facilitated by cilia and flagella associated protein 300. Ciliobrevin A targets the dynein motor protein, leading to an inhibition of dynein function that can compromise the role of cilia and flagella associated protein 300, as dynein is pivotal for ciliary beat and intraflagellar transport.
Further, Hydroxyurea impedes DNA synthesis by inhibiting ribonucleotide reductase, which affects the initiation of ciliogenesis during the G1 phase of the cell cycle, thus potentially inhibiting the assembly and function of cilia and flagella associated protein 300. Chloral hydrate impacts the polymerization of microtubules, structures integral to the formation of cilia and flagella, and thus can inhibit the assembly and function of cilia and flagella associated protein 300. Colchicine and Podophyllotoxin both bind to tubulin, but while Colchicine prevents its polymerization, Podophyllotoxin inhibits microtubule assembly, both resulting in disrupted ciliary function. Taxol, on the other hand, stabilizes microtubules, which can disrupt normal microtubule dynamics and consequently affect ciliary length and function, thus inhibiting the role of cilia and flagella associated protein 300. Griseofulvin also binds to tubulin, inhibiting its polymerization and thus ciliary assembly and function involving cilia and flagella associated protein 300. Lastly, an oxytocin antagonist can inhibit oxytocin receptor signaling, which is known to regulate ciliary beat frequency, and thereby affect the function of cilia and flagella associated protein 300.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide inhibits the Wnt/β-catenin signaling pathway, which is linked to ciliogenesis and, by extension, can inhibit the function of cilia and flagella associated protein 300 by reducing the functional assembly of cilia components. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine, a cyclin-dependent kinase inhibitor (CDK inhibitor), can inhibit cell cycle progression, which is crucial for ciliogenesis. This inhibition can disrupt the formation and function of structures that require cilia and flagella associated protein 300. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filament organization. The proper arrangement of actin is known to be crucial for cilia function and structure. By disrupting actin, cytochalasin D can inhibit the function of cilia and flagella associated protein 300, which is involved in ciliary movement and maintenance. | ||||||
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $136.00 $541.00 | ||
Ciliobrevin A is a specific inhibitor of the dynein motor protein. Dynein is essential for ciliary beat and intraflagellar transport, which are processes that cilia and flagella associated protein 300 is involved in. Inhibition of dynein function can, therefore, inhibit the function of cilia and flagella associated protein 300. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis, which is fundamental for cell division. Cells in the G1 phase of the cell cycle initiate ciliogenesis, hence hydroxyurea's action can inhibit ciliary assembly and function involving cilia and flagella associated protein 300. | ||||||
Trichloroacetaldehyde-13C2 | sc-474862 | 2.5 mg | $380.00 | |||
Chloral hydrate affects microtubule polymerization. Since cilia and flagella are microtubule-based structures, chloral hydrate can inhibit ciliary and flagellar assembly and function, including the activities of cilia and flagella associated protein 300. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, which are essential components of cilia. This inhibition can disrupt ciliary functions and processes that rely on cilia and flagella associated protein 300. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly. Since cilia and flagella associated protein 300 is involved in the structure and function of cilia and flagella which are composed of microtubules, podophyllotoxin can inhibit its function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and can disrupt normal microtubule dynamics. This stabilization can adversely affect ciliary length and function, thus inhibiting the role of cilia and flagella associated protein 300 in maintaining proper ciliary structure and function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, inhibiting its polymerization. This action can inhibit ciliary assembly and function, which involves cilia and flagella associated protein 300. | ||||||