5330417C22Rik Inhibitors

Elapor1 inhibitors are chemicals that can indirectly inhibit the function of the protein ELAPOR1 by targeting pathways and processes involved in autophagy and lysosomal functions. ELAPOR1 is implicated in the regulation of apoptosis and autophagy, particularly in the context of endosome-lysosome activities. Inhibitors such as Chloroquine and Bafilomycin A1 act by increasing lysosomal pH and inhibiting V-ATPase, respectively, which can affect the autophagic process and potentially the function of ELAPOR1 in this context.

Other inhibitors, like 3-Methyladenine, Wortmannin, LY294002, and SAR405, inhibit various PI3Ks which are crucial for the initiation and progression of autophagy, potentially altering ELAPOR1's involvement in these pathways. Compounds such as Spautin-1 and Vinblastine disrupt the formation and maturation of autophagosomes, a key step in autophagy where ELAPOR1 may have regulatory functions. E-64d and NH4Cl interfere with the degradation phase of autophagy, which can also indirectly affect ELAPOR1's role. MG-132 and Lys05 are examples of inhibitors that lead to the accumulation of autophagic substrates and increase lysosomal pH, respectively, which can further influence the functions associated with ELAPOR1 in the autophagy-lysosome pathway.