4931417G12Rik Inhibitors
The chemical class described as Fancd2os Inhibitors encompasses a variety of compounds that share the common feature of targeting key components in the DNA damage response (DDR) and repair pathways, which are intricately connected to the function of FANCD2OS. These chemicals are not direct antagonists of FANCD2OS but act on enzymatic activities and signaling events that are essential for the FA pathway, within which FANCD2OS may play a role.
The DDR inhibitors, such as Mirin, NU7026, KU-55933, and KU-60019, focus on disabling the functions of essential kinases like ATM and DNA-PK, which are responsible for signaling the presence of DNA damage and orchestrating the subsequent repair processes. By inhibiting these kinases, the chemicals may alter the activation state of the FA pathway, thereby influencing the cellular environment of FANCD2OS. ATR inhibitors like VE-821, VE-822, AZD0156, and AZD6738 work by blocking the ATR kinase, another pivotal regulator of the DDR. ATR's inhibition can lead to a compromised response to DNA damage, potentially affecting the FA pathway and the roles that FANCD2OS might serve.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
Inhibits the Mre11-Rad50-Nbs1 complex, which is crucial for the activation of the FA pathway, thereby influencing FANCD2OS. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
ATM kinase inhibitor, could affect the FA pathway by preventing the phosphorylation of key proteins involved in the DNA damage response. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
Improved derivative of KU-55933, more potent and specific in inhibiting ATM kinase, thereby influencing the FA pathway and possibly FANCD2OS. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR kinase inhibitor, can prevent ATR-mediated phosphorylation, which is required for the activation of the FA pathway, potentially impacting FANCD2OS. | ||||||
AZD-0156 | 1821428-35-6 | sc-507529 | 10 mg | $280.00 | ||
ATM kinase inhibitor, could reduce the efficacy of the FA pathway by inhibiting the response to DNA double-strand breaks, which may affect FANCD2OS. | ||||||
Ceralasertib | 1352226-88-0 | sc-507439 | 10 mg | $573.00 | ||
ATR inhibitor, could disrupt the FA pathway by preventing proper DNA damage response, potentially impacting the function of FANCD2OS. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $115.00 $431.00 | ||
Another CHK1 inhibitor, could similarly affect the FA pathway and possibly the role of FANCD2OS in DNA repair mechanisms. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
CHK1 inhibitor, could affect the integrity of the FA pathway and thus influence the cellular context in which FANCD2OS operates. | ||||||
LY2606368 | 1234015-52-1 | sc-507521 sc-507521A sc-507521B sc-507521C sc-507521D sc-507521E | 5 mg 10 mg 25 mg 100 mg 1 g 10 g | $176.00 $300.00 $500.00 $1900.00 $8000.00 $25000.00 | ||
CHK1 inhibitor, can lead to disruption of the FA pathway by affecting the DNA damage response, potentially impacting the function of FANCD2OS. | ||||||