2310079F23Rik Inhibitors
Chemical inhibitors classified as potential modulators of Trmt44 are not directly targeting the enzyme but are influencing the methylation pathways within the cell. These compounds typically act by modifying the availability or functionality of S-adenosylmethionine (SAM), the universal methyl donor for methylation reactions, or by altering the activity of other methyltransferases whose function may be intertwined with that of Trmt44. Some compounds, like adenosine periodate and periodate-oxidized adenosine, achieve this by oxidizing adenosine moieties, potentially disrupting the methylation cycle. Others, such as sinefungin and neplanocin A, are analogs that directly inhibit enzymes involved in the methylation cycle, thereby having an indirect impact on Trmt44 activity.
Notably, several of these chemicals, including BIX-01294, RG108, and decitabine, are primarily known to target DNA methylation. However, changes in DNA methylation patterns can have downstream effects on RNA processes, including the methylation of tRNA, which is the primary function of Trmt44. By influencing the global methylation landscape, these compounds could, therefore, indirectly modulate the activity of RNA methyltransferases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
SAH is a product of S-adenosyl-L-methionine (SAM)-dependent methylation reactions and can act as a competitive inhibitor of methyltransferases by binding to the SAM binding site, thereby reducing the methylation activity of enzymes like Trmt44. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
An analog of cytidine that gets incorporated into RNA and DNA and can inhibit DNA methyltransferases, thereby affecting the overall methylation landscape in the cell, which may indirectly alter Trmt44 function. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor, which can alter global methylation patterns and potentially modulate the activity of related RNA methyltransferases such as Trmt44. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a deoxycytidine analog that can inhibit DNA methyltransferases, which could lead to alterations in the methylation patterns of the cell, possibly affecting RNA methylation and Trmt44 activity. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
A vasodilator that has been found to inhibit DNA methyltransferase and could indirectly affect RNA methyltransferase enzymes by modulating the cellular methylation status. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $108.00 $189.00 $399.00 $616.00 | 1 | |
A local anesthetic that has been shown to demethylate DNA non-specifically and could potentially influence RNA methylation and Trmt44 activity through changes in the cellular methylation state. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
An antitumor antibiotic that binds to GC-rich DNA sequences, inhibiting transcription factors and potentially affecting downstream effects on methylation-related enzymes such as Trmt44. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
An alcohol deterrent that has been shown to inhibit DNA methyltransferase, which could potentially impact RNA methylation processes involving Trmt44. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol found in green tea that may modulate DNA methyltransferase activity and could indirectly influence RNA methyltransferases like Trmt44. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
A sesquiterpene lactone that can react with thiol groups and has been shown to inhibit NF-kB, a transcription factor; this inhibition can modulate gene expression and potentially influence methylation patterns in the cell, affecting enzymes such as Trmt44. | ||||||