1700019N12Rik Inhibitors
Chemical inhibitors of 1700019N12Rik can functionally inhibit the protein through various mechanisms by targeting specific signaling pathways. PD98059 and U0126, both MEK inhibitors, prevent the activation of the MEK/ERK pathway. This action leads to a decrease in ERK phosphorylation, which is crucial for the signaling processes that 1700019N12Rik relies on. Similarly, LY294002 and Wortmannin, which are PI3K inhibitors, obstruct the PI3K signaling cascade that operates upstream of other pathways, possibly affecting the activities of 1700019N12Rik. SB203580 specifically blocks p38 MAP kinase, a pathway associated with stress and inflammation responses. When p38 MAP kinase is inhibited, 1700019N12Rik may not receive the necessary signals for its activity if it is associated with this pathway.
In addition to these, SP600125 works by inhibiting JNK, a kinase that participates in stress signaling pathways. The inhibition of JNK by SP600125 disrupts the function of proteins like 1700019N12Rik if they rely on JNK-mediated signaling. Dasatinib and PP2 are inhibitors of Src family kinases, which are involved in a multitude of signaling pathways. By inhibiting these kinases, they can impede the function of 1700019N12Rik if it operates downstream or in conjunction with them. Rapamycin inhibits mTOR, a central player in cell growth and proliferation signaling, which can affect 1700019N12Rik if it is a part of the mTOR signaling network. ZM-447439, the Aurora kinase inhibitor, disrupts functions related to cell cycle control and mitosis, which could influence 1700019N12Rik if it is involved in these processes. Lastly, Bisindolylmaleimide I and Staurosporine serve as inhibitors of PKC and a broad spectrum of protein kinases, respectively. Both could impair the activity of 1700019N12Rik by inhibiting kinases that are necessary for its activation or function.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which in turn inhibits ERK phosphorylation. 1700019N12Rik, associated with signal transduction processes, would be functionally inhibited by the suppression of the MEK/ERK pathway because this pathway's inhibition can prevent the proper signaling required for 1700019N12Rik's function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. Since PI3K is upstream of many signaling pathways, including those that may involve 1700019N12Rik, the inhibition of PI3K would prevent the activation of downstream components that are necessary for 1700019N12Rik's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, leading to a decrease in ERK activation. As 1700019N12Rik may rely on MEK/ERK signaling for its function, the inhibition of this pathway by U0126 would result in reduced activity of 1700019N12Rik. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. The p38 MAP kinase pathway is implicated in cellular responses to stress and inflammation. Inhibiting this pathway with SB203580 can lead to the functional inhibition of 1700019N12Rik if it relies on signals transmitted through p38 MAPK for its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is involved in stress signaling pathways. By preventing JNK activity, SP600125 can disrupt functions of proteins like 1700019N12Rik if they are dependent on JNK signaling for activation or stabilization. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. By inhibiting PI3K, Wortmannin can block downstream signaling pathways essential for the function of 1700019N12Rik, leading to its functional inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. Src kinases are involved in various signaling pathways; thus, inhibition by Dasatinib could lead to the functional inhibition of 1700019N12Rik if it acts downstream of or in conjunction with Src family kinases. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically inhibits mTOR, which is a central component of the cellular growth and proliferation pathway. Inhibition of mTOR by Rapamycin could functionally inhibit 1700019N12Rik if it operates as part of the mTOR signaling pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is another Src family kinase inhibitor. It can functionally inhibit 1700019N12Rik by inhibiting Src kinases that may regulate or activate this protein. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases play a role in mitotic progression, and inhibition by ZM-447439 can lead to the functional inhibition of 1700019N12Rik if it is involved in cell cycle control or mitosis-related signaling pathways. | ||||||