1700015G11Rik Inhibitors
Chemical inhibitors of 1700015G11Rik function through various mechanisms to impede its activity within cellular processes. Staurosporine, a broad-spectrum protein kinase inhibitor, can block the phosphorylation of numerous proteins, including 1700015G11Rik, by targeting their kinase activators. This inhibition prevents the transfer of phosphate groups to these proteins, which is often a critical step for their activation. Similarly, LY294002 and Wortmannin target the PI3K pathway, leading to a decrease in the activation of proteins downstream of PI3K signaling. By obstructing this pathway, these inhibitors can reduce the phosphorylation and subsequent activation of 1700015G11Rik, effectively dampening its activity.
In addition to these, Rapamycin specifically inhibits the mTOR pathway, which can disrupt the processes that 1700015G11Rik may partake in, leading to a decrease in its functional influence. PD98059 and U0126, both MEK inhibitors, prevent the activation of the MEK-ERK pathway, which can also result in the reduction of 1700015G11Rik activity. SB203580 targets p38 MAP kinase, and by inhibiting this kinase, it can reduce the phosphorylation of substrates within this signaling pathway, potentially diminishing the functional role of 1700015G11Rik. SP600125 and PP2 inhibit JNK and Src family kinases, respectively, leading to a decrease in the signaling output of pathways that are involved in the regulation and activation of 1700015G11Rik. Dasatinib, with its multi-kinase inhibitory action, can suppress the activity of a range of kinases that would otherwise contribute to the functional state of 1700015G11Rik. Lastly, Y-27632 and Palbociclib inhibit ROCK and CDK4/6 kinases, respectively; by doing so, they can alter the actin cytoskeleton dynamics and cell cycle progression, processes in which 1700015G11Rik can be involved, thereby affecting its activity within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Inhibition of these kinases can lead to reduced phosphorylation and activation of downstream proteins, including 1700015G11Rik, thereby inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, this chemical can reduce the phosphorylation of downstream targets that are crucial for the activation and function of 1700015G11Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can decrease the phosphorylation of proteins in the PI3K pathway, potentially leading to the functional inhibition of 1700015G11Rik by limiting its activation signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits mTOR (mammalian target of rapamycin) which is involved in cell growth and proliferation. Inhibiting mTOR can disrupt processes downstream that 1700015G11Rik may be involved in, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which works upstream of ERK in the MAPK pathway. By inhibiting MEK, the subsequent ERK activation is reduced, which can functionally inhibit downstream proteins, including 1700015G11Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of ERK, leading to reduced function of proteins regulated by ERK, like 1700015G11Rik. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase can lead to a decrease in the phosphorylation of its substrates, which might be necessary for the functional activity of 1700015G11Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which, when inhibited, can lead to decreased function of proteins that are regulated by the JNK signaling pathway, potentially including 1700015G11Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases. By inhibiting these kinases, PP2 can reduce the activity of downstream proteins that rely on Src signaling for their function, which might include 1700015G11Rik. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a multi-kinase inhibitor with activity against Src family kinases and Bcr-Abl. Its inhibition of these kinases can lead to reduced signaling through pathways that activate proteins like 1700015G11Rik, thus inhibiting its function. | ||||||