1700007B14Rik Inhibitors
Chemical inhibitors of protein 1700007B14Rik engage in a variety of molecular interactions to impede its function. Staurosporine, a broad-spectrum protein kinase inhibitor, can interfere with the phosphorylation of 1700007B14Rik by targeting the responsible kinase. Similarly, Bisindolylmaleimide I specifically hinders Protein Kinase C (PKC), which may play a role in the activation or regulation of 1700007B14Rik. LY294002 and Wortmannin, both phosphoinositide 3-kinase (PI3K) inhibitors, can disrupt the PI3K/Akt pathway, which is crucial for numerous cellular processes that may include the proper functioning of 1700007B14Rik. Rapamycin, by inhibiting mTOR, can suppress cellular functions and pathways that involve 1700007B14Rik. PP2, targeting Src family tyrosine kinases, can also restrain the signaling required for 1700007B14Rik's activity.
Further inhibitory actions involve PD98059 and U0126, both of which inhibit MEK1/2, thus preventing the activation of the extracellular signal-regulated kinase (ERK) pathway that 1700007B14Rik may require. SP600125 inhibits the c-Jun N-terminal kinase (JNK), impacting signaling pathways linked to 1700007B14Rik. Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, can affect the Rho/ROCK pathway, potentially altering the function of 1700007B14Rik. Dasatinib, which inhibits BCR-ABL and Src family kinases, can suppress signaling pathways involving 1700007B14Rik. Lastly, SB203580, as a specific inhibitor of p38 MAP kinase, can halt signaling pathways that 1700007B14Rik may be involved in, thus impeding its function. Each of these inhibitors acts on different kinases or pathways that are upstream of 1700007B14Rik, leading to an overall inhibitory effect on the protein's activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is known to inhibit a wide range of protein kinases. Given that 1700007B14Rik is a protein that may be regulated by phosphorylation, staurosporine can inhibit the kinase responsible for its phosphorylation, thereby inhibiting 1700007B14Rik's function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I specifically inhibits Protein Kinase C (PKC). If 1700007B14Rik is activated or regulated by PKC-mediated pathways, then inhibition of PKC would result in the functional inhibition of 1700007B14Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K. The PI3K/Akt pathway is a fundamental signaling pathway that influences many cellular processes. Inhibition of PI3K would disrupt downstream signaling required for the function of 1700007B14Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and as mTOR is a central player in cell growth and survival, its inhibition can lead to the suppression of cellular functions and pathways that 1700007B14Rik is involved in, thereby inhibiting its activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. By inhibiting these kinases, PP2 can suppress the signaling that may be necessary for the activation or function of 1700007B14Rik. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. Inhibition of MEK therefore prevents activation of ERK, which could be necessary for the functional activity of 1700007B14Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, and by inhibiting JNK, it can inhibit the signaling pathways that may be required for the function of 1700007B14Rik. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. The Rho/ROCK pathway is implicated in various cellular functions, and inhibition of ROCK can lead to the inhibition of functions and pathways involving 1700007B14Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, similar to PD98059, and would thus inhibit the ERK pathway that may be necessary for the function of 1700007B14Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor like LY294002, and it would inhibit the PI3K/AKT pathway, potentially inhibiting downstream functions of 1700007B14Rik. | ||||||