1600014C10Rik Inhibitors
Chemical inhibitors of the protein encoded by 1600014C10Rik can play a significant role in modulating its activity within cellular signaling pathways. For instance, Wortmannin and LY294002 are both inhibitors of phosphoinositide 3-kinases (PI3K), and their interaction with the PI3K pathway can lead to the functional inhibition of the protein. When PI3K is inhibited, the activation or signaling pathways that the protein encoded by 1600014C10Rik might be involved in are likely to be impeded. This effect is due to the pivotal role PI3K plays in various cellular processes such as cell growth, proliferation, and survival, which are often regulated by the downstream signaling of PI3K. Similarly, Staurosporine, a potent protein kinase inhibitor, has a broad spectrum of targets and can suppress the activity of the protein encoded by 1600014C10Rik if it is a kinase or is regulated by phosphorylation events.
Furthermore, Rapamycin, by inhibiting mTOR, can result in the downregulation of the protein encoded by 1600014C10Rik if the protein functions within mTOR signaling pathways. mTOR is a central cell growth regulator, and its inhibition can lead to reduced activity of proteins associated with its pathway. In the MAPK/ERK pathway, PD0325901 and U0126, both MEK inhibitors, would preclude the necessary phosphorylation events for proteins that are regulated by this pathway, which could include the protein encoded by 1600014C10Rik. Additionally, SP600125 and SB203580, specific inhibitors of JNK and p38 MAPK respectively, could also lead to the inhibition of the protein if it is involved in stress response pathways governed by JNK or p38 MAPK. Dasatinib and PP2, as tyrosine kinase inhibitors, specifically target the phosphorylation process that is essential for the activation and function of many proteins. If the protein encoded by 1600014C10Rik is a tyrosine kinase or is activated by one, these inhibitors can suppress its activity. Lastly, Gefitinib and Sorafenib, which target EGFR and RAF kinases respectively, can modulate the activity of the protein encoded by 1600014C10Rik by obstructing the signaling cascades these kinases are part of, assuming the protein interacts with or is a component of these pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi that inhibits phosphoinositide 3-kinases (PI3K). Given that 1600014C10Rik is functionally associated with cellular processes modulated by PI3K signaling, inhibition of PI3K by Wortmannin can result in functional inhibition of 1600014C10Rik by preventing its activation or the signaling pathways it is involved in. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. If 1600014C10Rik acts as a kinase or is regulated by phosphorylation, Staurosporine can inhibit its activity by preventing the phosphorylation that is necessary for its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a chemical inhibitor of PI3K. If 1600014C10Rik's activity is mediated through PI3K/Akt signaling, the inhibition of PI3K by LY294002 would hinder the downstream signaling required for the functional activity of 1600014C10Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. As mTOR signaling is crucial for many cellular functions, including growth and metabolism, the inhibition of mTOR by Rapamycin can lead to the downregulation of processes that 1600014C10Rik may be involved in, resulting in its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). As JNK is involved in controlling gene expression related to inflammation and apoptosis, inhibition of JNK by SP600125 could suppress the pathways that regulate or are regulated by 1600014C10Rik, leading to its inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAPK. If 1600014C10Rik is involved in the p38 MAPK signaling pathway, the inhibition of p38 by SB203580 can inhibit the functional activity of 1600014C10Rik by interfering with its signaling mechanism. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream regulators of the ERK pathway. If the activity of 1600014C10Rik is dependent on ERK signaling, inhibition of MEK by U0126 would inhibit the signaling required for the function of 1600014C10Rik. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor with broad specificity. If 1600014C10Rik is a tyrosine kinase or is activated by tyrosine kinases, inhibition of these kinases by Dasatinib would result in the functional inhibition of 1600014C10Rik. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. If the functionality of 1600014C10Rik is regulated by Src family kinases, inhibition of Src kinases by PP2 would lead to the inhibition of 1600014C10Rik's activity. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. If 1600014C10Rik is part of the EGFR signaling pathway, inhibition of EGFR by Gefitinib would result in the functional inhibition of 1600014C10Rik by hindering the pathway's activation. | ||||||