1500035H01Rik Inhibitors
Chemical inhibitors of 1500035H01Rik can intervene in various signaling pathways to modulate the activity of this protein. Wortmannin and LY294002 are examples that target the PI3K/AKT pathway, which is upstream of 1500035H01Rik. By inhibiting PI3K, these chemicals can reduce the phosphorylation and activation of AKT, subsequently leading to the inhibition of 1500035H01Rik. Another inhibitor, MK-2206, acts more directly by inhibiting AKT itself, hence disrupting the signaling cascade that would normally result in the activation of 1500035H01Rik. Triciribine also follows this route, preventing the phosphorylation and activation of AKT, therefore diminishing the functional activity of 1500035H01Rik.
Moving to other pathways, Rapamycin targets the mTOR pathway, specifically mTORC1, which interacts with signals that affect 1500035H01Rik activity. The inhibition of mTORC1 by Rapamycin can result in decreased activity of proteins in this pathway, including 1500035H01Rik. In the MAPK pathway, U0126, PD98059, and SL327 inhibit MEK1/2, which are upstream of ERK1/2, leading to a reduction in ERK activity. With ERK activity downregulated, the regulatory influence on 1500035H01Rik is reduced, resulting in its functional inhibition. Similarly, SP600125 and SB203580 block the JNK and p38 MAPK pathways, respectively, both of which can have downstream effects on the activity of 1500035H01Rik. Lastly, PP2 and Dasatinib inhibit Src family kinases, affecting multiple signaling pathways that intersect with the functional regulation of 1500035H01Rik. By inhibiting these kinases, these chemicals can suppress the activity of 1500035H01Rik through multiple, possibly intersecting, signaling routes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K which is upstream of AKT signaling; since 1500035H01Rik is involved in AKT pathway, reducing PI3K activity leads to decreased AKT activity, thus inhibiting 1500035H01Rik function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K, leading to a downregulation of the PI3K/AKT pathway; this would inhibit 1500035H01Rik by reducing the phosphorylation and activation of downstream targets involved in its function. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
Directly inhibits AKT, which is known to be involved in the signaling pathway of 1500035H01Rik; by inhibiting AKT, MK-2206 inhibits the activation of 1500035H01Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTORC1, part of the mTOR pathway which is involved in the signaling cascade that regulates 1500035H01Rik activity; inhibition of this pathway decreases the activity of proteins regulated by mTORC1, including 1500035H01Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Inhibits MEK1/2, which are upstream of ERK1/2 in the MAPK pathway; since 1500035H01Rik is regulated by the MAPK pathway, inhibition by U0126 would lead to reduced ERK activity and subsequent inhibition of 1500035H01Rik activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK which impacts ERK pathway activity; PD98059’s inhibition of MEK leads to decreased ERK signaling, reducing the functional activity of 1500035H01Rik. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
Also an inhibitor of MEK, leading to a reduction in ERK signaling; inhibited ERK signaling means lower regulatory influence on 1500035H01Rik, resulting in its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, thereby disrupting the JNK signaling pathway; since JNK can regulate proteins like 1500035H01Rik, SP600125's inhibition of JNK leads to a decrease in 1500035H01Rik activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Specifically inhibits p38 MAPK, which is involved in stress responses; inhibition of p38 MAPK by SB203580 would result in decreased regulation of proteins like 1500035H01Rik within its signaling pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Inhibits Src family kinases, which impacts multiple signaling pathways that regulate 1500035H01Rik; by inhibiting Src kinases, PP2 indirectly leads to functional inhibition of 1500035H01Rik. | ||||||