1110049F12Rik Inhibitors
Chemical inhibitors of 1110049F12Rik can impact its function by targeting various signaling pathways and kinases. Staurosporine is a broad-spectrum kinase inhibitor, which means it can inhibit a wide range of protein kinases that may be essential for the phosphorylation events that 1110049F12Rik depends on. Similarly, Bisindolylmaleimide I specifically inhibits protein kinase C, which could impair any signaling cascade that requires this kinase for 1110049F12Rik's function. LY294002 and Wortmannin both serve as inhibitors of phosphoinositide 3-kinases (PI3K), suggesting that if 1110049F12Rik operates within a PI3K-dependent pathway, its activity can be reduced. Rapamycin acts on the mammalian target of rapamycin (mTOR), and by inhibiting mTOR, it can affect protein synthesis and other cellular processes that 1110049F12Rik might influence.
Further, the MEK inhibitors U0126 and PD98059 can prevent the activation of ERK1/2 kinases in the MAPK pathway, which can disrupt the signaling cascades involving 1110049F12Rik. SB203580, as a selective inhibitor of p38 MAP kinase, could impair the stress response and cytokine signaling that may involve 1110049F12Rik. SP600125, by inhibiting c-Jun N-terminal kinase (JNK), can affect gene expression and cell fate decisions that 1110049F12Rik might regulate. Dasatinib, being a broad-spectrum tyrosine kinase inhibitor, can prevent the activation of various signaling pathways that regulate 1110049F12Rik. Lapatinib, as a dual inhibitor of EGFR and HER2/neu, can block crucial receptors and the downstream signaling such as the PI3K/AKT pathway, which may involve 1110049F12Rik. Lastly, PP2, an inhibitor of Src family tyrosine kinases, can impede signaling cascades that 1110049F12Rik is part of, thereby inhibiting its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting these kinases, it disrupts phosphorylation events critical for many signaling pathways, potentially leading to the inhibition of 1110049F12Rik if it relies on kinase activity for its function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This chemical acts as a specific inhibitor of protein kinase C. By targeting this kinase, it could inhibit signaling pathways that may be necessary for the function of 1110049F12Rik, provided that 1110049F12Rik requires protein kinase C activity for its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). The inhibition of PI3K can lead to a decrease in downstream signaling necessary for the function of 1110049F12Rik, assuming that this protein's activity is PI3K-dependent. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin functions similarly to LY294002 as a PI3K inhibitor. It could inhibit downstream signaling processes that involve 1110049F12Rik, effectively reducing its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a key kinase in cell growth and proliferation. Inhibition of mTOR can lead to a reduction in protein synthesis and other processes that might be essential for the function of 1110049F12Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that prevents the activation of ERK1/2 kinases in the MAPK pathway. This inhibition can disrupt signaling cascades where 1110049F12Rik may play a role, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively blocks MEK1/2, which could inhibit ERK activation. If 1110049F12Rik operates within the MAPK/ERK pathway, this would result in its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38, it can inhibit the stress response and cytokine signaling pathways that may involve the functional activity of 1110049F12Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK), which plays a role in gene expression and cell fate decisions. If 1110049F12Rik is part of pathways regulated by JNK, then its inhibition could reduce the functional activity of 1110049F12Rik. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor. By inhibiting tyrosine kinases, it can prevent the activation of various signaling pathways. If 1110049F12Rik is regulated by such kinases, its activity would be inhibited. | ||||||