βA1/3-crystallin Inhibitors
βA1/3-crystallin inhibitors refers to a class of chemical compounds that specifically target and modulate the activity of βA1/3-crystallin proteins within biological systems. βA1/3-crystallins are a subset of crystallin proteins found predominantly in the eye lens, where they play crucial roles in maintaining lens transparency and refractive properties. These proteins are part of the larger family of crystallins, which are essential structural components contributing to the optical clarity of the lens. The inhibitors designed for βA1/3-crystallins are crafted to interact with these proteins in a selective manner, exerting regulatory control over their function.
βA1/3-crystallin inhibitors are intricately designed to interfere with the natural processes associated with βA1/3-crystallin function. This chemical class typically comprises small molecules with specific binding motifs that enable them to interact with the target proteins, influencing their conformation or activity. Understanding the detailed three-dimensional structure of βA1/3-crystallins has been instrumental in the rational design of inhibitors, allowing for precise molecular interactions that modulate the function of these proteins. The development and study of βA1/3-crystallin inhibitors contribute to our broader understanding of the molecular mechanisms underlying lens transparency and may have implications for various research areas related to ocular biology and vision science.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can inhibit the glycation of lens proteins including crystallins, thereby preserving their structure and function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol in green tea, has been shown to protect crystallins from oxidative stress by acting as an antioxidant, thus potentially maintaining lens transparency. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can chelate metal ions and act as an antioxidant, offering protection to crystallin proteins from oxidative damage. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate signal transduction pathways involved in oxidative stress responses, possibly preserving crystallin structure and function. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid, or vitamin C, can reduce oxidative stress in the lens, potentially preventing crystallin aggregation and maintaining clarity. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine can act as a precursor to glutathione, an antioxidant that may help maintain crystallin proteins' proper structure by reducing oxidative stress. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid can regenerate other antioxidants and chelate metals, which could prevent oxidative damage to crystallin proteins. | ||||||
Xanthophyll | 127-40-2 | sc-220391 sc-220391A | 25 mg 100 mg | $250.00 $900.00 | 2 | |
Lutein, a carotenoid, can absorb harmful UV radiation and act as an antioxidant, potentially safeguarding crystallin proteins from UV-induced oxidative stress. | ||||||
Zeaxanthin | 144-68-3 | sc-205544 sc-205544A | 500 µg 1 mg | $270.00 $463.00 | 5 | |
Zeaxanthin serves a similar role to lutein, protecting the crystallin proteins from oxidative stress by filtering blue light and functioning as an antioxidant. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Vitamin E is a lipid-soluble antioxidant that can protect cell membranes from oxidative damage, potentially preserving the function of membrane-bound crystallins. | ||||||