Date published: 2025-9-7

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Vav 抗体 (D-7): sc-8039

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说明书
  • Vav 抗体 D-7 是小鼠单克隆 IgG1 κ,Vav抗体, 在26篇文献中引用,规格为200 µg/ml
  • 与氨基酸110-320结合,映射到human起源的Vav p95的中心域
  • Vav 抗体 (D-7) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Vav p95
  • 抗Vav抗体(D-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Vav (D-7): sc-8039免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是Vav Antibody (D-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Vav Antibody (D-7) 打包提供(请参阅下面的订购信息)。

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関連項目

Vav抗体(D-7)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的Vav蛋白。抗Vav抗体(D-7)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。Vav蛋白,也称为Vav1或p95Vav,在信号传导中起着至关重要的作用,特别是在造血细胞中,Vav1是唯一表达的。Vav蛋白具有独特的结构,包括一个N端螺旋-环-螺旋结构域和一个亮氨酸拉链结构,这两个结构对于调节与其他蛋白的相互作用和促进下游信号传导至关重要。SH2结构域的存在进一步表明Vav1蛋白是酪氨酸激酶的底物,将受体激活与细胞反应联系起来。Vav蛋白的致癌潜力首先通过基因转移试验确定,凸显了Vav1蛋白在癌症生物学中的重要性。了解Vav蛋白的结构特征和功能意义,研究人员能够更好地探索Vav1蛋白在造血信号传导中的作用,以及作为各种疾病治疗靶标的潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Vav 抗体 (D-7) 参考文献:

  1. 干扰素-α信号促进 p95Vav 从细胞核到细胞质的重新分布,并形成涉及 Vav, Ku80 和 Tyk2 的多亚基复合物。  |  Adam, L., et al. 2000. Biochem Biophys Res Commun. 267: 692-6. PMID: 10673353
  2. vav 原癌基因的产物定义了一类新的酪氨酸蛋白激酶底物。  |  Bustelo, XR., et al. 1992. Nature. 356: 68-71. PMID: 1311423
  3. 含有 SH2 结构域和转录因子基团的 vav 原癌基因产物的酪氨酸磷酸化。  |  Margolis, B., et al. 1992. Nature. 356: 71-4. PMID: 1531699
  4. T细胞信号传导中的Vav家族蛋白。  |  Tybulewicz, VL. 2005. Curr Opin Immunol. 17: 267-74. PMID: 15886116
  5. vav原癌基因氨基末端螺旋-环-螺旋结构域的缺失会激活其转化潜能。  |  Katzav, S., et al. 1991. Mol Cell Biol. 11: 1912-20. PMID: 2005887
  6. vav 原癌基因的激活机制。  |  Coppola, J., et al. 1991. Cell Growth Differ. 2: 95-105. PMID: 2069873
  7. 具有酪氨酸激酶活性的受体的信号转导。  |  Ullrich, A. and Schlessinger, J. 1990. Cell. 61: 203-12. PMID: 2158859
  8. vav是一种新型人类癌基因,源自造血细胞中普遍表达的一个基因座。  |  Katzav, S., et al. 1989. EMBO J. 8: 2283-90. PMID: 2477241
  9. Vav家族交换因子:综合调控和功能观点。  |  Bustelo, XR. 2014. Small GTPases. 5: 9. PMID: 25483299
  10. p95vav 与核蛋白 Ku-70 相关联。  |  Romero, F., et al. 1996. Mol Cell Biol. 16: 37-44. PMID: 8524317
  11. VAV信号转导分子家族。  |  Bustelo, XR. 1996. Crit Rev Oncog. 7: 65-88. PMID: 9109498
  12. Vav的结构和功能。  |  Romero, F. and Fischer, S. 1996. Cell Signal. 8: 545-53. PMID: 9115846

订购信息

产品名称产品编号规格价格数量收藏夹

Vav 抗体 (D-7)

sc-8039
200 µg/ml
$316.00

Vav (D-7): m-IgG Fc BP-HRP 套装

sc-528210
200 µg Ab; 10 µg BP
$354.00

Vav (D-7): m-IgGκ BP-HRP 套装

sc-520533
200 µg Ab, 40 µg BP
$354.00

Vav (D-7): m-IgG1 BP-HRP 套装

sc-542819
200 µg Ab; 20 µg BP
$354.00

Vav 抗体 (D-7) AC

sc-8039 AC
500 µg/ml, 25% agarose
$416.00

Vav 抗体 (D-7) HRP

sc-8039 HRP
200 µg/ml
$316.00

Vav 抗体 (D-7) FITC

sc-8039 FITC
200 µg/ml
$330.00

Vav 抗体 (D-7) PE

sc-8039 PE
200 µg/ml
$343.00

Vav 抗体 (D-7) Alexa Fluor® 488

sc-8039 AF488
200 µg/ml
$357.00

Vav 抗体 (D-7) Alexa Fluor® 546

sc-8039 AF546
200 µg/ml
$357.00

Vav 抗体 (D-7) Alexa Fluor® 594

sc-8039 AF594
200 µg/ml
$357.00

Vav 抗体 (D-7) Alexa Fluor® 647

sc-8039 AF647
200 µg/ml
$357.00

Vav 抗体 (D-7) Alexa Fluor® 680

sc-8039 AF680
200 µg/ml
$357.00

Vav 抗体 (D-7) Alexa Fluor® 790

sc-8039 AF790
200 µg/ml
$357.00

DOes this antibody recognize only Vav1 or also Vav2?

Asked by: Meztli
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

Does this antibody also recognize vav2 and vav3? did you check it? thanks.

Asked by: yiftah
Thank you for your question. This antibody is specific for Vav p95 and should not cross-react with Vav2. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2022-08-19

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with Vav Antibody (D-7): sc-8039?

Asked by: Trav11
Thank you for your question. We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Technical Support 5
Date published: 2017-02-08
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Rated 5 out of 5 by from 功能很出色效果很好,很准确,很灵敏,条带也很好看,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
Date published: 2020-10-09
Rated 4 out of 5 by from Great featuresI bought this a month a ago and am so happy that i use this product to get my results.
Date published: 2017-10-11
Rated 5 out of 5 by from Fantastic antibody!This monoclonal Vav Antibody (D-7) is an excellent choice with clean and specific results in Western blot. It has been featured in over a dozen publications, and is very popular for use in immunoprecipitation and Western blots.
Date published: 2017-01-26
Rated 4 out of 5 by from Robust bands seen in WB using JurkatRobust bands seen in WB using Jurkat, MOLT-4 and CTLL-2 whole cell lysates. -SCBT QC
Date published: 2015-06-27
Rated 4 out of 5 by from Publishable data in WB using rat cardiomyocytesPublishable data in WB using rat cardiomyocytes. -SCBT Publication Review
Date published: 2015-06-12
Rated 4 out of 5 by from Publishable data in IP using mouse PreT2017Publishable data in IP using mouse PreT2017 T cells -SCBT Publication Review
Date published: 2015-05-20
Rated 5 out of 5 by from works well no problemsworks well no problems
Date published: 2015-04-28
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-04-15
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Vav 抗体 (D-7) is rated 4.3 out of 5 by 9.
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