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USP15 Antibody (2D5) - Western Blotting - Image 34000
USP15 抗体 (2D5): sc-100629. Hep G2 全细胞裂解液中 USP15 表达的 Western 印迹分析.
USP15 抗体 (2D5): sc-100629. Hep G2 全细胞裂解液中 USP15 表达的 Western 印迹分析.

USP15 抗体 (2D5): sc-100629

5.0(5)
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说明书
  • USP15抗体(2D5)是小鼠单克隆IgG1 κ, 在12篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组USP15
  • 推荐用于 mouse, rat 和 human 来源的USP15 WB, IP, IF 和 ELISA检测
  • 关于如何获取USP15 (2D5): sc-100629的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是USP15 Antibody (2D5) for WB applications. 的首选辅助检测试剂，这些试剂现与USP15 Antibody (2D5) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外USP抗体，包括USP10, USP11, USP13, USP14, USP15, USP18, USP2, USP20, USP21, USP22, USP25, USP29, USP3, USP30, USP31和USP32

USP15抗体（2D5）是一种IgG1 κ小鼠单克隆USP15抗体，可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的USP15。USP15抗体（2D5）为非偶联抗USP15抗体形式。泛素（Ub）途径涉及三个连续的酶促步骤，这些步骤促进Ub和Ub样分子与特定蛋白质底物的结合。通过使用能够添加或去除泛素的多种酶，Ub途径控制着许多细胞内过程，如信号转导、转录激活和细胞周期进程。USP15（泛素特异性肽酶15），也被称为UNPH4，是肽酶C19蛋白家族的成员。USP15在肾、肝、胎盘、卵巢、肺、胸腺、心脏和骨骼肌中表达，定位于细胞质和细胞核，含有一个DUSP结构域，作为去泛素化酶发挥作用，从泛素化蛋白质和泛素融合前体中裂解泛素残基，从而保护这些蛋白质免受蛋白酶体降解。USP15通过其DUSP结构域在COP9信号体（CSN）复合物的调节中发挥作用。由于选择性剪接事件，USP15存在三种异构体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

USP15 抗体 (2D5) 参考文献:

  1. 与 UNP 肿瘤蛋白相关的新型人类泛素特异性蛋白酶 USP15 的鉴定, 功能表征和染色体定位，以及人类泛素特异性蛋白酶的系统命名法。  |  Baker, RT., et al. 1999. Genomics. 59: 264-74. PMID: 10444327
  2. 小鼠泛素特异性蛋白酶 Usp15 的分离与鉴定。  |  Angelats, C., et al. 2003. Mamm Genome. 14: 31-46. PMID: 12532266
  3. CSN缔合作用的去泛素化酶USP15的锌指对于拯救E3连接酶Rbx1至关重要。  |  Hetfeld, BK., et al. 2005. Curr Biol. 15: 1217-21. PMID: 16005295
  4. 人类泛素特异性蛋白酶 15 DUSP 结构域的溶液结构。  |  de Jong, RN., et al. 2006. J Biol Chem. 281: 5026-31. PMID: 16298993
  5. CSN 通过 IkappaBalpha 的去泛素化来控制 NF-kappaB。  |  Schweitzer, K., et al. 2007. EMBO J. 26: 1532-41. PMID: 17318178
  6. 微管末端结合蛋白1（EB1）的泛素依赖性蛋白水解受COP9信号体控制：对微管丝稳定性的可能影响  |  Peth, A., et al. 2007. J Mol Biol. 368: 550-63. PMID: 17350042
  7. USP15在癌症和其他疾病中的作用：从不同的功能到治疗靶点。  |  Li, YC., et al. 2022. Biomedicines. 10: PMID: 35203682
  8. USP15通过TRAF6-BECN1信号轴负调控肺癌进展，促进自噬诱导。  |  Kim, MJ., et al. 2022. Cell Death Dis. 13: 348. PMID: 35422093
  9. ER、PR和HER2受体的缺失促进了PARP1在三重阴性乳腺癌中USP15依赖性的稳定。  |  Sun, X., et al. 2023. Nat Cancer. 4: 716-733. PMID: 37012401
  10. TRIM21/USP15平衡了AFLS4的稳定性和胃肠道间质瘤对伊马替尼的耐药性。  |  Cui, Z., et al. 2024. Br J Cancer. 130: 526-541. PMID: 38182686
  11. 去泛素化酶USP15通过葡萄糖代谢重塑驱动胃癌的恶性进展。  |  Huangfu, L., et al. 2024. J Exp Clin Cancer Res. 43: 235. PMID: 39164728
  12. 预测人类不明基因的编码序列。IX.100 个可在体外编码大型蛋白质的脑部新 cDNA 克隆的完整序列。  |  Nagase, T., et al. 1998. DNA Res. 5: 31-9. PMID: 9628581

订购信息

产品名称产品编号规格价格数量收藏夹

USP15 抗体 (2D5)

sc-100629
100 µg/ml
$333.00

USP15 (2D5): m-IgG Fc BP-HRP 套装

sc-539699
100 µg Ab; 10 µg BP
$354.00

USP15 (2D5): m-IgG1 BP-HRP 套装

sc-541660
100 µg Ab; 20 µg BP
$354.00

Which peptide is the antibody raised against? I am looking at the two different isoforms of USP15 and would be interested in an antibody that recognizes both forms (the long isoform 981aa (NP_001239007.1) and the short 235aa ( NP_001239008.1)).

Asked by: leag
Thank you for your question. This mouse monoclonal antibody, USP15 (2D5): sc-100629, is not raised against a peptide. It is raised against a full length recombinant protein of human origin. The exact epitope recognized has not been determined.
Answered by: Technical Support
Date published: 2017-09-27

I need to use an antibody to detect the protein in samples of canine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 2
Date published: 2017-02-15
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Rated 5 out of 5 by from Works well in IF and WBVery specific antibody, good nuclear localization in IF and single clean bands in Western Blot.
Date published: 2017-01-19
Rated 5 out of 5 by from Produced beautiful immunofluorescence nuclearProduced beautiful immunofluorescence nuclear staining in paraformaldehyde-fixed HeLa cells. -SCBT QC
Date published: 2015-04-02
Rated 5 out of 5 by from Strong band in WB HeLa whole cell lysateStrong band in WB HeLa whole cell lysate. -SCBT QC
Date published: 2015-02-04
Rated 5 out of 5 by from Good specificity in WB in Hep G2 whole cell lysateGood specificity in WB in Hep G2 whole cell lysate. -SCBT QC
Date published: 2015-01-17
Rated 5 out of 5 by from ClearClear, strong band detected in WB in non-transfected 293T, human USP15 transfected 293T and Hep G2 whole cell lysates. -SCBT QC
Date published: 2015-01-16
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USP15 抗体 (2D5) is rated 5.0 out of 5 by 5.
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