uricase Antibody (F-7): sc-166070

uricase Antibody (F-7) is a mouse monoclonal IgG2a antibody that detects uricase in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Uricase, also known as urate oxidase, plays a crucial role in purine metabolism by catalyzing the oxidation of uric acid to allantoin, a more soluble compound that can be easily excreted from the body. This enzymatic activity is particularly important as elevated levels of uric acid can lead to conditions such as gout and kidney stones. Humans and certain primates lack functional uricase due to a genetic mutation, which has implications for the management of hyperuricemia and related disorders. The absence of uricase in humans may also contribute to the neurological symptoms observed in conditions like Lesch-Nyhan syndrome, highlighting the enzyme′s significance in both metabolic and neurological health. Uricase is primarily located in the liver, where uricase is associated with peroxisomes and exists as a tetramer, underscoring uricase′s specialized role in cellular metabolism. The gene encoding uricase is mapped to human chromosome 1p22, and understanding uricase structure and function can provide insights into therapeutic targets for diseases associated with purine metabolism. anti-uricase antibody (F-7) is an essential tool for researchers investigating the complexities of uric acid metabolism and its implications in various health conditions.

The preferred uricase antibody is uricase Antibody (C-11): sc-166214.