Date published: 2025-9-8
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TRP1 Antibody (G-9) - Western Blotting - Image 109605
TRP1 抗体 (G-9): sc-166857. B16-F0 全细胞裂解液中 TRP1 表达的 Western 印迹分析.
TRP1 抗体 (G-9): sc-166857. B16-F0 全细胞裂解液中 TRP1 表达的 Western 印迹分析.

TRP1 抗体 (G-9): sc-166857

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说明书
  • TRP1 抗体 G-9 是小鼠单克隆 IgG3 κ，TRP1抗体, 在40篇文献中引用，规格为200 µg/ml
  • 免疫human物种的TRP1的氨基酸448-537
  • 推荐用于 mouse, rat 和 human 来源的TRP1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取TRP1 (G-9): sc-166857的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP 是TRP1 抗体 (G-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与TRP1 抗体 (G-9) 组合成套装提供。 (请参阅下面的订购信息)。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外Tyrosinase Related Protein抗体，包括TRP2

TRP1抗体（G-9）是一种IgG3κ型小鼠单克隆TRP1抗体（也称为CAS2抗体、TYRP1抗体、Catalase B抗体或DHICA氧化酶抗体），可通过蛋白质印迹、免疫沉淀、免疫荧光、免疫组织化学（P）和酶联免疫吸附测定法检测小鼠、大鼠和人类来源的TRP1蛋白。TRP1抗体（G-9）可作为非共轭抗TRP1抗体使用。酪氨酸酶（TYR）是一种I型膜蛋白和含铜酶，参与黑色素（脊椎动物中发现的主要色素）的产生。黑色素的生成需要TYR的酶活性，TYR催化黑色素生物合成中酪氨酸羟化的关键和限速步骤。影响TYR活性的缺陷会导致各种形式的白化病。与TYR相关的蛋白质TRP1和TRP2也特异性表达于黑色素细胞中，它们同样有助于黑色素体内的黑色素合成。包括TYR在内的TRPs都具有相似的跨膜区，含有两个金属结合区和一个富含半胱氨酸的表皮生长因子基序，并定位于黑色素体膜上。然而，这些蛋白质具有不同的催化活性，它们各自有助于黑色素生物聚合物的生物合成。人们认为TRPs以多酶复合物的形式存在，因为这些蛋白质会聚集在一起，而TRP1的表达也有助于稳定黑色素细胞中的TYR。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TRP1 抗体 (G-9) 参考文献:

  1. 内源性表达的Trp1对Ca2+选择性、储存钙通道的Ca2+进入途径的贡献。  |  Brough, GH., et al. 2001. FASEB J. 15: 1704-1710. PMID: 11481220
  2. 钙调蛋白调节从体内钙库释放钙与通过内源性TRP1通道激活钙流入之间的延迟期。  |  Vaca, L. and Sampieri, A. 2002. J Biol Chem. 277: 42178-87. PMID: 12196518
  3. 克隆和序列分析来自Pichia anomala（菌株K）的TRP1基因编码磷酸核糖酰基苯丙氨酸异构酶。  |  Friel, D., et al. 2003. Yeast. 20: 1331-7. PMID: 14663825
  4. 裂殖酵母Schizosaccharomyces pombe中复合基因座trp1的组织。  |  Thuriaux, P., et al. 1982. Curr Genet. 6: 13-8. PMID: 24186364
  5. 酵母TRP1基因中一个AT丰富的二聚体对称区域是启动子元件。  |  Kim, SY., et al. 1988. Mol Gen Genet. 211: 472-6. PMID: 2835633
  6. 通过Trp-1转录分析定量检测弥散性黑色素瘤细胞，揭示肺部转移的随机分布。  |  Kyjacova, L., et al. 2021. J Clin Med. 10: PMID: 34830742
  7. 黑色素生成途径中的一种新的酶功能。酪氨酸酶相关蛋白-1（TRP1）的 5,6-二羟基吲哚-2-羧酸氧化酶活性。  |  Jiménez-Cervantes, C., et al. 1994. J Biol Chem. 269: 17993-8000. PMID: 8027058
  8. 小鼠胰腺β细胞的四个trp1基因变体的鉴定。  |  Sakura, H. and Ashcroft, FM. 1997. Diabetologia. 40: 528-32. PMID: 9165220
  9. 储存操作的钙离子进入促进了表达 Trp1 的肺内皮细胞的形状变化。  |  Moore, TM., et al. 1998. Am J Physiol. 275: L574-82. PMID: 9728053
  10. 黑色素生成复合物内的分子相互作用：来自 B16 小鼠黑色素瘤的酪氨酸酶和 TRP1 异二聚体的形成。  |  Jiménez-Cervantes, C., et al. 1998. Biochem Biophys Res Commun. 253: 761-7. PMID: 9918801

订购信息

产品名称产品编号规格价格数量收藏夹

TRP1 抗体 (G-9)

sc-166857
200 µg/ml
$316.00

TRP1 (G-9): m-IgG3 BP-HRP 套装

sc-550558
200 µg Ab; 40 µg BP
$354.00

Hello, Does your company provide Alexa Fluor® 546-labelled TRP1 Antibody (G-9): sc-166857, like the one provided in TRP2/DCT Antibody (C-9) Alexa Fluor® 546 sc-74439 AF546? Thanks, Jenny

Asked by: Jenny
Thank you for your question. At this time, we do not offer a conjugated form for this antibody.
Answered by: BlakeJ
Date published: 2025-04-23

Is the antibody sc166857-AF 488 still available to buy?

Asked by: Julieta Marino
Thank you for your question. Yes, the Alexa Fluor® 488 (AF488) conjugated version of this antibody, TRP1 (G-9): sc-166857 AF488, is still available to purchase as a special order. Please contact our Special Orders Department by phone at (800) 457-3801 option 2, or e-mail <specialorders@scbt.com> to request a quote.
Answered by: Technical Support
Date published: 2017-04-26

Can TRP1 (G-9): sc-166857 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, TRP1 (G-9): sc-166857 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Great antibodyWorks very well to detect TRP1 expression in melanoma cells leading to strong and clear bands (dilution 1:1000).
Date published: 2023-11-30
Rated 5 out of 5 by from TRP1 antibodyThis antibody is great on western blot. The band is clear and clean.
Date published: 2023-08-06
Rated 5 out of 5 by from TRP-1 antibody is goodIt's a great antibody. It work well on western blot in B16F10.
Date published: 2023-07-25
Rated 5 out of 5 by from Great antibody for WBThis primary antibody worked very well in Western blot.
Date published: 2021-03-31
Rated 4 out of 5 by from Strong bandStrong band in fluorescent WB of mouse melanocytes,some background though
Date published: 2020-02-03
Rated 4 out of 5 by from funziona beneQuesto anticorpo dà un buon segnale. Lo consiglio.
Date published: 2019-02-23
Rated 5 out of 5 by from strong signalTRP1 (sc-166857) gives strong Western blotting signal in human MNT1 cells
Date published: 2018-04-17
Rated 5 out of 5 by from Very strong and specific!!Reacts with mouse melanoma cell line B16F10 extracts and human melanoma cell line Skmel30. No corresponding signal in non-melanoma human cell line 293T.
Date published: 2018-02-03
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TRP1 抗体 (G-9) is rated 4.8 out of 5 by 13.
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