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TNF-R1 Antibody (55R-170) - Flow Cytometry - Image 5948
TNF-R1 抗体 (55R-170) FITC: sc-12746 FITC. 人体外周血白细胞的 FCM 分析. 黑线直方图代表同型对照--正常亚美尼亚仓鼠 IgG: sc-2864.
TNF-R1 Antibody (55R-170) - Flow Cytometry - Image 5948
TNF-R1 抗体 (55R-170) FITC: sc-12746 FITC. 人体外周血白细胞的 FCM 分析. 黑线直方图代表同型对照--正常亚美尼亚仓鼠 IgG: sc-2864.
TNF-R1 Antibody (55R-170) - Flow Cytometry - Image 5949
TNF-R1 抗体 (55R-170) PE: sc-12746 PE. 小鼠外周血白细胞的 FCM 分析. 黑线直方图代表同型对照, 正常亚美尼亚仓鼠 IgG: sc-2875.
TNF-R1 抗体 (55R-170) FITC: sc-12746 FITC. 人体外周血白细胞的 FCM 分析. 黑线直方图代表同型对照--正常亚美尼亚仓鼠 IgG: sc-2864.

TNF-R1 抗体 (55R-170): sc-12746

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说明书
  • TNF-R1 Antibody (55R-170) is a Armenian hamster monoclonal IgG provided at 200 µg/ml
  • 针对纯化的mouse来源TNF-R1的细胞外结构域的抗原
  • 推荐用于 mouse, rat 和 human 来源的TNF-R1 IP 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 还提供无叠氮化物的中和，sc-12746 L，200 µg/0.1 ml
  • 看 TNF-R1 (H-5): sc-8436，可查看有标记的 TNF-R1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成TNF-R1 抗体 (55R-170)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外TNF-R抗体，包括TNF-R2

肿瘤坏死因子（TNF）是一种多功能细胞因子，其功能通过两种不同的细胞表面受体来介导。这些受体分别被称为TNF-R1和TNF-R2，在大多数细胞类型上表达。TNF的大部分功能主要是通过TNF-R1介导的，而TNF-R2的信号传导则较少，仅限于免疫系统的细胞。这两种蛋白属于不断增长的TNF和神经生长因子（NGF）受体超家族，其中包括FAS、CD30、CD27和CD40。该超家族的成员是类型I膜蛋白，其序列同源性仅限于细胞外区域。TNF-R1与FAS以及三种结构不相关的信号蛋白TRADD、FADD和RIP共享一种被称为"死亡结构域"的基序。这种"死亡结构域"是传导凋亡信号所必需的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TNF-R1 抗体 (55R-170) 参考文献:

  1. TNF-R1和CD95内化对凋亡和抗凋亡信号的影响。  |  Schütze, S. and Schneider-Brachert, W. 2009. Results Probl Cell Differ. 49: 63-85. PMID: 19132322
  2. TNF/TNF-R1通路参与阿霉素诱导的急性无菌性炎症。  |  Kaczmarek, A., et al. 2013. Cell Death Dis. 4: e961. PMID: 24336081
  3. TNF-R1作为预测先兆子痫的早期标志物。  |  E Holanda Moura, SB., et al. 2016. J Matern Fetal Neonatal Med. 29: 897-903. PMID: 25758630
  4. TNF-R1与R92Q突变的分子动力学和细胞内信号传导。  |  Agulló, L., et al. 2015. J Neuroimmunol. 289: 12-20. PMID: 26616867
  5. TNF-R1和FADD介导UVB诱导的角膜上皮细胞K+通道活化  |  Boersma, PM., et al. 2017. Exp Eye Res. 154: 1-9. PMID: 27818316
  6. TNF-α和TNF-R1调节布比卡因诱导的脊髓背根神经节神经元的凋亡。  |  Zhang, K., et al. 2018. Eur J Pharmacol. 833: 63-68. PMID: 29802833
  7. 静脉和动脉TNF-R1可预测急性蛛网膜下腔出血的预后和并发症。  |  Fragata, I., et al. 2019. Neurocrit Care. 31: 107-115. PMID: 30673997
  8. AT-Lipoxin A4对TNF-α/TNF-R1信号的下调可能是缓解SAP相关肺损伤的重要机制。  |  Yu, S., et al. 2019. Mediators Inflamm. 2019: 9019404. PMID: 31097921
  9. 在海马CA1区，年轻和成年沙鼠在短暂前脑缺血后受损神经元和激活星形胶质细胞中TNF-α和TNF-R1表达的差异。  |  Lee, CH., et al. 2021. Mol Med Rep. 24: PMID: 34212986
  10. ADAM17 在 TNF-R1 介导的人 U937 和 Jurkat 细胞死亡和存活中的作用  |  Fritsch, J., et al. 2021. Cells. 10: PMID: 34831323

订购信息

产品名称产品编号规格价格数量收藏夹

TNF-R1 抗体 (55R-170)

sc-12746
200 µg/ml
$322.00

TNF-R1 抗体 (55R-170) FITC

sc-12746 FITC
200 µg/ml
$336.00

TNF-R1 抗体 (55R-170) L

sc-12746 L
200 µg/0.1 ml
$322.00

TNF-R1 抗体 (55R-170) PE

sc-12746 PE
200 µg/ml
$349.00

How can TNF-R1 (55R-170): sc-12746 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: TinTin
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-12746 PE) or fluoroscein (sc-12746 FITC).
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by JL from Produced superb FCM data for human peripheralProduced superb FCM data for human peripheral blood leukocytes. -SCBT QC
Date published: 2015-06-01
Rated 5 out of 5 by HC from WB positive with mouse OTII spleen cellsWB positive with mouse OTII spleen cells. -SCBT Publication Review
Date published: 2015-04-26
Rated 5 out of 5 by TO from Published good quality flow cytometry dataPublished good quality flow cytometry data in mouse C57BL/6 ES cells. -SCBT Publication Review
Date published: 2015-03-30
Rated 5 out of 5 by LR from Publishable IHC data in mouse myocytesPublishable IHC data in mouse myocytes. -SCBT Publication Review
Date published: 2015-02-08
Rated 5 out of 5 by ET from Good WB publishable data gathered with humanGood WB publishable data gathered with human Jurkat cells. -SCBT Publication Review
Date published: 2015-01-08
Rated 5 out of 5 by JT from Superb FCM data of mouse peripheral bloodSuperb FCM data of mouse peripheral blood leukocytes. -SCBT QC
Date published: 2013-03-03
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TNF-R1抗体 (55R-170) is rated 5.0 out of 5 by 6.
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