Tafluprost (free acid) CAS: 209860-88-8
MF: C22H28F2O5
MW: 410.45
A very strong FP receptor agonist.

Tafluprost (free acid) (CAS 209860-88-8)

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备用名: (5E)-7-{2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoic acid
应用; Tafluprost (free acid) is a very strong FP receptor agonist
CAS号码: 209860-88-8
分子量: 410.45
分子式: C22H28F2O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Tafluprost (free acid) is a member of 17-phenyl trinor prostaglandin F (17-phenyl trinor PGF2α) derivatives of research interest for in vitro glaucoma studies. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. Tafluprost (free acid) is a very strong PGFR (FP receptor) agonist, with a Ki of 0.4 nM.


参考文献

1. Woodward, D.F., et al. 2001. Surv Ophthalmol. 45: S337-S345. PMID: 11434936
2. Maxey, K.M., et al. 2002. Surv Ophthalmol. 47: 34-40. PMID: 12204699
3. Balapure, A.K., et al. 1989. Biochem Pharmacol. 38: 2375-2381. PMID: 2751699
4. Lake, S., et al. 1994. FEBS Lett. 355: 317-325. PMID: 7988697
5. Resul, B., et al. 1993. J. Med. Chem. 36: 243-248. PMID: 8423596
6 Takagi, Y., et al. 2004. Exp Eye Res. 78: 767-776. PMID: 15037111

规划 :
A solution in methyl acetate
物理状态 :
Liquid
溶解度 :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), PBS (3 mg/ml, pH7.2), and water (3 mg/ml at 25° C).
保存 :
Store at -20° C
沸点 :
57° C
Ki 数据 :
FP receptor : Ki= 0.4 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
9978917
MDL 号码 :
MFCD08062149
SMILES :
C1[[email protected]@H]([[email protected]@H]([[email protected]]([[email protected]@H]1O)/C=C/C(COC2=CC=CC=C2)(F)F)C/C=C\\CCCC(=O)O)O

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