Date published: 2025-9-8
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SREBP-1 Antibody (E-4) - Western Blotting - Image 352830
SREBP-1 抗体 (E-4): sc-17755. A-431 (A), A549 (B), Jurkat (C) 和 MCF7 (D) 全细胞裂解液中 SREBP-1 表达的 Western 印迹分析.
SREBP-1 抗体 (E-4): sc-17755. A-431 (A), A549 (B), Jurkat (C) 和 MCF7 (D) 全细胞裂解液中 SREBP-1 表达的 Western 印迹分析.

SREBP-1 抗体 (E-4): sc-17755

4.6(8)
寫評論提問

说明书
  • SREBP-1抗体(E-4)是小鼠单克隆IgG2b κ, 在15篇文献中引用，规格为200 µg/ml
  • 免疫human物种的SREBP-1的氨基酸41-200
  • 抗-SREBP-1 抗体 (E-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 SREBP-1
  • 抗SREBP-1抗体（E-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-17755 X, 200 µg/0.1 ml)
  • 关于如何获取SREBP-1 (E-4): sc-17755的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2b BP-HRP 是 SREBP-1 抗体 (E-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与SREBP-1 抗体 (E-4) 组合成套装提供。 (请参阅下面的订购信息)。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 SREBP 抗体 包括 SREBP-2

SREBP-1抗体（E-4）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学（IHC）和酶联免疫吸附测定（ELISA）等方法检测小鼠、大鼠和人类来源的SREBP-1蛋白。SREBP-1 (E-4) 抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶、藻红蛋白、异硫氰酸荧光素和多种 Alexa Fluor® 结合物。SREBP-1 蛋白通过调节胆固醇和脂肪酸合成相关基因的表达，在脂质代谢中起着至关重要的作用。SREBP-1蛋白以前体形式合成，位于核膜和内质网中，在胆固醇耗尽时，通过蛋白水解释放可溶性片段，进入细胞核，激活靶基因的转录，包括低密度脂蛋白受体。该受体对于内吞携带胆固醇的脂蛋白至关重要，从而维持细胞和血浆胆固醇水平。SREBP-1调节对于细胞稳态至关重要，因为过量的胆固醇会导致细胞功能障碍，并导致动脉粥样硬化等疾病。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

订购信息

产品名称产品编号规格价格数量收藏夹

SREBP-1 抗体 (E-4)

sc-17755
200 µg/ml
$316.00

SREBP-1 (E-4): m-IgG Fc BP-HRP 套装

sc-525483
200 µg Ab; 10 µg BP
$354.00

SREBP-1 (E-4): m-IgG2b BP-HRP 套装

sc-549567
200 µg Ab; 10 µg BP
$354.00

SREBP-1 抗体 (E-4) X

sc-17755 X
200 µg/0.1 ml
$316.00

SREBP-1 抗体 (E-4) AC

sc-17755 AC
500 µg/ml, 25% agarose
$416.00

SREBP-1 抗体 (E-4) HRP

sc-17755 HRP
200 µg/ml
$316.00

SREBP-1 抗体 (E-4) FITC

sc-17755 FITC
200 µg/ml
$330.00

SREBP-1 抗体 (E-4) PE

sc-17755 PE
200 µg/ml
$343.00

SREBP-1 抗体 (E-4) Alexa Fluor® 488

sc-17755 AF488
200 µg/ml
$357.00

SREBP-1 抗体 (E-4) Alexa Fluor® 546

sc-17755 AF546
200 µg/ml
$357.00

SREBP-1 抗体 (E-4) Alexa Fluor® 594

sc-17755 AF594
200 µg/ml
$357.00

SREBP-1 抗体 (E-4) Alexa Fluor® 647

sc-17755 AF647
200 µg/ml
$357.00

SREBP-1 抗体 (E-4) Alexa Fluor® 680

sc-17755 AF680
200 µg/ml
$357.00

SREBP-1 抗体 (E-4) Alexa Fluor® 790

sc-17755 AF790
200 µg/ml
$357.00

Does this antibody identifies both mature and immature forms of SREBP1?

Asked by: Monteiro
Thank you for your question. This mouse monoclonal antibody was raised against amino acids 41-200 of SREBP-1 of human origin, but the antibody has not been epitope mapped so further information regarding the epitope location is not available at this time. In Western blot experiments the precursor form is most commonly detected with this antibody.
Answered by: Tech Service
Date published: 2020-01-30

When should the TransCruz reagent sc-17755 X be used instead of the standard form sc-17755?

Asked by: TinTin
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Excellent antibodyIt is highly sensitive antibody, with very little background.
Date published: 2018-07-31
Rated 4 out of 5 by from Overall OKI used 1:500. For some reason can't see in A549 (even with longer exposion). Supposed size should be 125 (135) KD, but H1299 is about 150KD, and A549 have light band about 200KD? Not consider A549 can visualize bands. H1299 have a light band at around 80KD. Not sure what are they
Date published: 2017-05-23
Rated 5 out of 5 by from Versatile AntibodyThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and ELISA. Strong, clear signal with little to no background. Beautiful tissue staining. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2017-01-25
Rated 4 out of 5 by from WB data obtained when using this antibodyWB data obtained when using this antibody on HeLa nuclear extract. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Good WB publishable data gathered with ratGood WB publishable data gathered with rat liver hepatocytes. -SCBT Publication Review
Date published: 2015-04-15
Rated 5 out of 5 by from Strong signal in human SREBPStrong signal in human SREBP-1 transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-02-28
Rated 4 out of 5 by from Publishable data obtained via ChIP on HepG2 cellsPublishable data obtained via ChIP on HepG2 cells. -SCBT Publication Review
Date published: 2015-01-22
Rated 5 out of 5 by from Publishable IHC staining with paraffinPublishable IHC staining with paraffin-embedded human SZ95 seboytes. -SCBT QC
Date published: 2013-11-11
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SREBP-1 抗体 (E-4) is rated 4.6 out of 5 by 8.
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