Sptrx-2 Antibody (KK-M5): sc-135567

Sptrx-2 Antibody (KK-M5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sptrx-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Sptrx-2 antibody (KK-M5) is available as a non-conjugated format. Sptrx-2, also known as spermatid-specific thioredoxin-2, NME8, CILD6, SPTRX2, or TXNDC3 (thioredoxin domain-containing protein 3), is a 588 amino acid cytoplasmic and testis-specific protein that plays a crucial role in sperm maturation. Sptrx-2 is expressed exclusively in primary spermatocytes and round spermatids, where Sptrx-2 is essential during the final stages of sperm tail maturation in the testis and epididymis. This process involves the formation of extensive disulfide bonds in fibrous sheath proteins, which are vital for the structural integrity and functionality of sperm. Sptrx-2 contains a thioredoxin domain and three inactive nucleoside diphosphate kinase (NDK) domains that lack the active histidine residue, indicating that these domains do not possess NDP kinase activity. Defects in the gene encoding Sptrx-2 are linked to primary ciliary dyskinesia type 6, an autosomal recessive disorder characterized by abnormalities in motile cilia, which can lead to conditions such as Kartagener syndrome when associated with situs inversus.

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Sptrx-2 Antibody (KK-M5) References:

1. Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.  |  Sadek, CM., et al. 2001. Genes Cells. 6: 1077-90. PMID: 11737268
2. Cis- and trans-acting gene regulation is associated with osteoarthritis.  |  Mahr, S., et al. 2006. Am J Hum Genet. 78: 793-803. PMID: 16642435
3. Genetic association analysis of RHOB and TXNDC3 in osteoarthritis.  |  Loughlin, J., et al. 2007. Am J Hum Genet. 80: 383-6; author reply 386-7. PMID: 17304710
4. A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia.  |  Duriez, B., et al. 2007. Proc Natl Acad Sci U S A. 104: 3336-41. PMID: 17360648
5. Sequence analysis of 21 genes located in the Kartagener syndrome linkage region on chromosome 15q.  |  Geremek, M., et al. 2008. Eur J Hum Genet. 16: 688-95. PMID: 18270537
6. DNAI1 mutations explain only 2% of primary ciliary dykinesia.  |  Failly, M., et al. 2008. Respiration. 76: 198-204. PMID: 18434704
7. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis.  |  Shi, D., et al. 2008. Arthritis Res Ther. 10: R54. PMID: 18471322
8. Mutations in DNAH5 account for only 15% of a non-preselected cohort of patients with primary ciliary dyskinesia.  |  Failly, M., et al. 2009. J Med Genet. 46: 281-6. PMID: 19357118
9. Ciliary defects and genetics of primary ciliary dyskinesia.  |  Escudier, E., et al. 2009. Paediatr Respir Rev. 10: 51-4. PMID: 19410201

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sptrx-2 Antibody (KK-M5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Sptrx-2 Antibody (KK-M5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sptrx-2 Antibody (KK-M5) Specifications

Alternate Product Name: Sptrx-2

Product Clone Name: KK-M5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 530-587

Epitope Target: Sptrx-2

Epitope Species: human

Product Reactivity/Detection: Sptrx-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Sptrx-2 Antibody (KK-M5): N/A