SEMA6D Antibody (A-8): sc-393258
- SEMA6D Antibody (A-8) is a mouse monoclonal IgG2a κ SEMA6D antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 369-420 mapping within an internal region of SEMA6D of human origin
- SEMA6D Antibody (A-8) is recommended for detection of SEMA6D of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SEMA6D Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SEMA6D Antibody (A-8) for WB applications. These reagents are now offered in bundles with SEMA6D Antibody (A-8) (see ordering information below).
SEMA6D Antibody (A-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects SEMA6D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SEMA6D antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SEMA6D, also known as semaphorin-6D, is a 1073 amino acid member of the semaphorin family, which plays a crucial role in the development and maintenance of neuronal connections. SEMA6D is primarily localized to the cell membrane or cytoplasm, depending on the isoform, and is essential for the remodeling of neuronal networks. SEMA6D functions by providing a stop signal for dorsal root ganglion neurons as they reach their target areas, thereby guiding the intricate wiring of the nervous system. One PSI domain and one semaphorin domain in SEMA6D′s structure are significant, as these domains mediate interactions with other proteins and signaling pathways that influence neuronal growth and guidance. SEMA6D undergoes alternative splicing, resulting in seven distinct isoforms, which may have different functional roles in neural development and plasticity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SEMA6D Antibody (A-8) References:
- Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. | Qu, X., et al. 2002. J Biol Chem. 277: 35574-85. PMID: 12110693
- Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling. | Toyofuku, T., et al. 2004. Nat Cell Biol. 6: 1204-11. PMID: 15543137
- Invasive growth: a two-way street for semaphorin signalling. | Comoglio, PM., et al. 2004. Nat Cell Biol. 6: 1155-7. PMID: 15573094
- The human cumulus--oocyte complex gene-expression profile. | Assou, S., et al. 2006. Hum Reprod. 21: 1705-19. PMID: 16571642
- Semaphorins in vascular development and head and neck squamous cell carcinoma-induced angiogenesis. | Sun, Q., et al. 2008. Oral Oncol. 44: 523-31. PMID: 18203650
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEMA6D Antibody (A-8) | sc-393258 | 200 µg/ml | $322.00 | |||
SEMA6D Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-530408 | 200 µg Ab; 10 µg BP | $361.00 | |||
SEMA6D Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-523876 | 200 µg Ab, 40 µg BP | $361.00 | |||
SEMA6D Antibody (A-8) AC | sc-393258 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SEMA6D Antibody (A-8) HRP | sc-393258 HRP | 200 µg/ml | $322.00 | |||
SEMA6D Antibody (A-8) FITC | sc-393258 FITC | 200 µg/ml | $336.00 | |||
SEMA6D Antibody (A-8) PE | sc-393258 PE | 200 µg/ml | $349.00 | |||
SEMA6D Antibody (A-8) Alexa Fluor® 488 | sc-393258 AF488 | 200 µg/ml | $364.00 | |||
SEMA6D Antibody (A-8) Alexa Fluor® 546 | sc-393258 AF546 | 200 µg/ml | $364.00 | |||
SEMA6D Antibody (A-8) Alexa Fluor® 594 | sc-393258 AF594 | 200 µg/ml | $364.00 | |||
SEMA6D Antibody (A-8) Alexa Fluor® 647 | sc-393258 AF647 | 200 µg/ml | $364.00 | |||
SEMA6D Antibody (A-8) Alexa Fluor® 680 | sc-393258 AF680 | 200 µg/ml | $364.00 | |||
SEMA6D Antibody (A-8) Alexa Fluor® 790 | sc-393258 AF790 | 200 µg/ml | $364.00 |