Date published: 2025-9-7

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SCML2 抗体 (H-4): sc-376289

5.0(2)
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说明书
  • SCML2抗体(H-4)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列561-825位于mouse物种的SCML2的C-terminus
  • 推荐用于 mouse, rat 和 human 来源的SCML2 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 SCML2 抗体 (H-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与SCML2 抗体 (H-4) 组合成套装提供。 (请参阅下面的订购信息)。

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    在果蝇中,Polycomb(PcG)基因家族编码的染色质蛋白在胚胎发育中抑制同源异型盒基因位点时是必需的。PcG蛋白与三胸家族(trxG)协同作用,在胚胎发育过程中激活同源异型盒基因的表达。SCM(中腿上的性梳)是一种参与转录抑制的重要果蝇PcG蛋白。SCML2(中腿上的性梳样2)是这种果蝇蛋白的人类同源物。SCML2是一种广泛表达的蛋白质,主要在胎盘、睾丸和胸腺中表达。DNA损伤时,SCML2可能被ATR或ATM磷酸化。由于选择性剪接,该蛋白存在两种异构体。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    SCML2 抗体 (H-4) 参考文献:

    1. USP7 与 SCML2 合作调节 PRC1 的活性。  |  Lecona, E., et al. 2015. Mol Cell Biol. 35: 1157-68. PMID: 25605328
    2. 多聚核蛋白 SCML2 与 USP7 结合,在雄性减数分裂过程中抵消 XY 染色质中组蛋白 H2A 的泛素化。  |  Luo, M., et al. 2015. PLoS Genet. 11: e1004954. PMID: 25634095
    3. SCML2通过调节组蛋白H2A泛素化建立雄性生殖细胞表观遗传组。  |  Hasegawa, K., et al. 2015. Dev Cell. 32: 574-88. PMID: 25703348
    4. RNF8和SCML2合作调控泛素化和H3K27乙酰化,以实现性染色体上基因的逃逸激活。  |  Adams, SR., et al. 2018. PLoS Genet. 14: e1007233. PMID: 29462142
    5. 多聚胞蛋白 SCML2 促进 H3K27me3 在雄性生殖细胞中建立双价域。  |  Maezawa, S., et al. 2018. Proc Natl Acad Sci U S A. 115: 4957-4962. PMID: 29686098
    6. SCML2能促进精子发生后期的异染色质组织。  |  Maezawa, S., et al. 2018. J Cell Sci. 131: PMID: 30097555
    7. 一个快速进化的结构域--SCML2 DNA 结合重复序列--有助于小鼠 SCML2† 的染色质结合。  |  Maezawa, S., et al. 2019. Biol Reprod. 100: 409-419. PMID: 30137219
    8. 多聚酶蛋白SCML2通过精子染色质介导父系表观遗传。  |  Sakashita, A., et al. 2023. Nucleic Acids Res. 51: 6668-6683. PMID: 37283086
    9. SCML2通过调节p53和CHK1的稳定性,促进肿瘤细胞对DNA损伤的耐受性。  |  Peng, Q., et al. 2023. Cell Death Differ. 30: 1849-1867. PMID: 37353627
    10. YAP1和多聚核糖体组蛋白SCML2之间不和谐的相互作用决定了细胞的命运。  |  Boston, AM., et al. 2023. iScience. 26: 107964. PMID: 37810219

    订购信息

    产品名称产品编号规格价格数量收藏夹

    SCML2 抗体 (H-4)

    sc-376289
    200 µg/ml
    $316.00

    SCML2 (H-4): m-IgG Fc BP-HRP 套装

    sc-540540
    200 µg Ab; 10 µg BP
    $354.00

    SCML2 (H-4): m-IgG1 BP-HRP 套装

    sc-542192
    200 µg Ab; 20 µg BP
    $354.00

    Can SCML2 (H-4): sc-376289 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: Randy McDonald
    Thank you for your question. Yes, SCML2 (H-4): sc-376289 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Excellent immunoperoxidase nuclear stainingExcellent immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human testis tissue. -SCBT QC
    Date published: 2015-03-27
    Rated 5 out of 5 by from Great Western Blot data of SCML2 expressionGreat Western Blot data of SCML2 expression in F9 whole cell lysate. -SCBT QC
    Date published: 2014-07-23
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    SCML2 抗体 (H-4) is rated 5.0 out of 5 by 2.
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