Date published: 2025-9-7

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RXRγ 抗体 (A-2): sc-365252

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说明书
  • RXR gamma 抗体 A-2 是小鼠单克隆 IgG2b κ,RXRγ抗体, 在18篇文献中引用,规格为200 µg/ml
  • 免疫human物种的RXRγ的氨基酸1-105
  • RXR gamma 抗体 (A-2) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 RXRγ
  • 抗RXR gamma抗体(A-2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于ChIP的TransCruz试剂(sc-365252 X, 200 µg/0.1 ml)
  • 关于如何获取RXRγ (A-2): sc-365252免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2b BP-HRP">m-IgG2b BP-HRPm-IgGκ BP-HRP是RXRγ Antibody (A-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与RXRγ Antibody (A-2) 打包提供(请参阅下面的订购信息)。

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関連項目

RXRγ抗体(A-2)是一种IgG2b κ小鼠单克隆RXR gamma抗体(也被称为核受体亚家族2组B成员3抗体、NR2B3抗体、RXR-gamma抗体、RXRG抗体、类视黄醇X受体(RXR)家族核受体C抗体、RXRC抗体、视黄酸(RA)依赖性抗增殖信号受体抗体,或视黄酸受体、甲状腺激素受体、维生素D受体关联核受体抗体),可通过WB、IP、IF和ELISA检测人类来源的RXR gamma蛋白。RXRγ抗体(A-2)既有非偶联的抗RXR gamma抗体形式,也有多种偶联形式的抗RXR gamma抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。目前已经发现两种类视黄醇受体家族,即RARs和RXRs。视黄酸受体(RARs)包括RARα、RARβ和RARγ,它们对全反式视黄酸都具有高亲和力,并且与甲状腺激素受体、维生素D3受体和蜕皮激素受体属于同一类核转录因子。RARs的配体结合域高度保守,RAR异构体在发育过程中和成熟生物体内以不同的模式表达。类视黄醇X受体(RXR)家族的成员,包括RXRα、RXRβ和RXRγ,它们可被9-顺式-RA激活,这是全反式-RA的一种立体和光异构体,在体内肝脏和肾脏中均有表达,可能是一种广泛使用的激素。与RAR亚家族一样,RXR受体在其DNA结合域和配体结合域上彼此密切相关,并且由不同染色体位点的独立基因编码。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

RXRγ 抗体 (A-2) 参考文献:

  1. 9 顺式维甲酸立体异构体可结合并激活核受体 RXR alpha。  |  Levin, AA., et al. 1992. Nature. 355: 359-61. PMID: 1309942
  2. 9- 顺式维甲酸是维甲酸 X 受体的高亲和力配体。  |  Heyman, RA., et al. 1992. Cell. 68: 397-406. PMID: 1310260
  3. 编码核视黄醇 X 受体 RXR alpha、RXR beta 和 RXR gamma 的小鼠 Rxr 基因座图谱。  |  Hoopes, CW., et al. 1992. Genomics. 14: 611-7. PMID: 1358808
  4. 视黄酸受体 DNA 结合和视黄酸结合特性的表征。  |  Yang, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 3559-63. PMID: 1850832
  5. 果蝇 EcR 基因编码一种蜕皮激素受体,它是类固醇受体超家族的一个新成员。  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
  6. 由人类第 12 号染色体上的基因编码的功能性维甲酸受体。  |  Ishikawa, T., et al. 1990. Mol Endocrinol. 4: 837-44. PMID: 2172793
  7. 表达蛋白质组学预测了上皮性卵巢癌发展过程中 RXR-γ 的损失。  |  Kalra, RS. and Bapat, SA. 2013. PLoS One. 8: e70398. PMID: 23936423
  8. 用蛋白质组学预测上皮性卵巢癌发展过程中 RXR-γ 的缺失  |  Kalra, RS. and Bapat, SA. 2019. Methods Mol Biol. 2019: 1-14. PMID: 31359385
  9. 细胞骨架蛋白 Zyxin 通过破坏 RXRγ 核受体母体 mRNA 的稳定性来抑制维甲酸信号传导  |  Parshina, EA., et al. 2022. Int J Mol Sci. 23: PMID: 35628438
  10. 合理设计新型 RXR 激动剂支架,实现对 RXRα、RXRβ 和 RXRγ 的单亚型偏好。  |  Adouvi, G., et al. 2023. J Med Chem. 66: 333-344. PMID: 36533416
  11. 磷酸化增强了甲状腺激素受体与视黄醇 X 受体的靶基因序列依赖性二聚化。  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
  12. RXR γ 缺失小鼠显然是正常的,而复合 RXR α +/-/RXR beta -/-/RXR γ -/- 突变小鼠是可以存活的。  |  Krezel, W., et al. 1996. Proc Natl Acad Sci U S A. 93: 9010-4. PMID: 8799145

订购信息

产品名称产品编号规格价格数量收藏夹

RXRγ 抗体 (A-2)

sc-365252
200 µg/ml
$316.00

RXRγ (A-2): m-IgGκ BP-HRP 套装

sc-522180
200 µg Ab, 40 µg BP
$354.00

RXRγ (A-2): m-IgG2b BP-HRP 套装

sc-549006
200 µg Ab; 10 µg BP
$354.00

RXRγ 抗体 (A-2) X

sc-365252 X
200 µg/0.1 ml
$316.00

RXRγ 抗体 (A-2) AC

sc-365252 AC
500 µg/ml, 25% agarose
$416.00

RXRγ 抗体 (A-2) HRP

sc-365252 HRP
200 µg/ml
$316.00

RXRγ 抗体 (A-2) FITC

sc-365252 FITC
200 µg/ml
$330.00

RXRγ 抗体 (A-2) PE

sc-365252 PE
200 µg/ml
$343.00

RXRγ 抗体 (A-2) Alexa Fluor® 488

sc-365252 AF488
200 µg/ml
$357.00

RXRγ 抗体 (A-2) Alexa Fluor® 546

sc-365252 AF546
200 µg/ml
$357.00

RXRγ 抗体 (A-2) Alexa Fluor® 594

sc-365252 AF594
200 µg/ml
$357.00

RXRγ 抗体 (A-2) Alexa Fluor® 647

sc-365252 AF647
200 µg/ml
$357.00

RXRγ 抗体 (A-2) Alexa Fluor® 680

sc-365252 AF680
200 µg/ml
$357.00

RXRγ 抗体 (A-2) Alexa Fluor® 790

sc-365252 AF790
200 µg/ml
$357.00

Does it work on paraffin sections?

Asked by: Shubha
Thank you for your question. We have not tested for Paraffin sections but it should work.
Answered by: BlakeJ
Date published: 2024-04-24

Is this antibody predicted to work on mouse tissue?

Asked by: Liyam
Thank you for your question. Unfortunately this antibody has only been validated on human samples, and is not recommended or warrantied for use on mouse samples.
Answered by: Tech Service
Date published: 2019-01-16

What is the recommended fixation method for immunofluorescence staining with RXRγ (A-2): sc-365252 monoclonal antibody?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from great for WBIt works great for WB mouse protein in tissue, 3% BSA in PBST, at 1:1000 dilution.
Date published: 2018-02-20
Rated 5 out of 5 by from great immunofluorescent stainingit works great on the frozen section of retinal organoid.
Date published: 2017-08-25
Rated 4 out of 5 by from Works well with antigen retrievalTried a sample of this monoclonal antibody and found it works well in our fixed frozen retinal sections.
Date published: 2017-07-26
Rated 5 out of 5 by from Exceptional immunofluorescence nuclear andExceptional immunofluorescence nuclear and cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-01-30
Rated 5 out of 5 by from Satisfactory Western Blot data of RXR expressionSatisfactory Western Blot data of RXR expression in non-transfected and human RXR transfected 293 whole cell lysates. -SCBT QC
Date published: 2014-03-19
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RXRγ 抗体 (A-2) is rated 4.8 out of 5 by 5.
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