Date published: 2025-9-7

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RKIP 抗体 (D-5): sc-365973

5.0(3)
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说明书
  • RKIP抗体(D-5)是小鼠单克隆IgG1 κ, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于rat物种的RKIP的C-terminus附近的氨基酸143-174之间
  • 推荐用于 mouse, rat 和 human 来源的RKIP WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 RKIP 抗体 (D-5) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与RKIP 抗体 (D-5) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Raf激酶抑制蛋白(RKIP)是一种胞质蛋白,最初被鉴定为在脑组织中表达的磷脂酰乙醇胺结合蛋白(PBP),并从睾丸液中分泌。此外,RKIP是通过酵母双杂交筛选人T细胞库而鉴定出的,该库旨在鉴定与丝氨酸/苏氨酸激酶Raf-1的BXB激酶结构域相关的蛋白。随后的体外和体内研究表明,RKIP与Raf-1的活性形式和非活性形式结合,从而调节MAP激酶通路的信号级联。RKIP与激酶活性Raf-1的特异性结合竞争性抑制Raf-1底物MEK的结合和激活。反过来,RKIP通过减少MEK效应蛋白(包括ERK1和ERK2)的激活以及随后诱导AP-1介导的转录来影响下游MAP激酶信号传导。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

RKIP 抗体 (D-5) 参考文献:

  1. Raf激酶抑制蛋白(RKIP):一种生理调节剂和未来治疗靶点。  |  Zeng, L., et al. 2008. Expert Opin Ther Targets. 12: 1275-87. PMID: 18781826
  2. Raf 激酶抑制蛋白 RKIP 可增强糖原合酶激酶-3β 的信号传递。  |  Al-Mulla, F., et al. 2011. Cancer Res. 71: 1334-43. PMID: 21303975
  3. Raf激酶抑制蛋白(RKIP)的表达是葡萄膜黑色素瘤转移的预测指标。  |  Caltabiano, R., et al. 2014. Histol Histopathol. 29: 1325-34. PMID: 24763848
  4. Raf激酶抑制蛋白介导的信号传导抑制肝癌的侵袭和转移。  |  Wu, X., et al. 2016. Biochim Biophys Acta. 1860: 384-91. PMID: 26116914
  5. Raf激酶抑制蛋白介导肠上皮细胞凋亡并促进人类和小鼠的IBD。  |  Lin, W., et al. 2017. Gut. 66: 597-610. PMID: 26801887
  6. Raf激酶抑制蛋白(RKIP)抑制人胶质瘤细胞系在体外中的细胞迁移和侵袭。  |  Lei, X., et al. 2015. Int J Clin Exp Pathol. 8: 14214-20. PMID: 26823735
  7. Raf 激酶抑制蛋白通过 NF-κB 和 ERK 通路调节氧-葡萄糖剥夺诱导的 PC12 细胞凋亡。  |  Su, L., et al. 2016. J Clin Biochem Nutr. 59: 86-92. PMID: 27698534
  8. 在心肌氧化应激增强的条件下,Raf激酶抑制蛋白介导心肌纤维化。  |  Kazakov, A., et al. 2018. Basic Res Cardiol. 113: 42. PMID: 30191336
  9. 作为拉夫激酶抑制蛋白 (RKIP) 结合配体的海洋天然产物研究  |  Parate, S., et al. 2021. Mar Drugs. 19: PMID: 34677480
  10. Vicagrel在人体肠道中被Raf激酶抑制蛋白水解。  |  Zhu, T., et al. 2022. Biopharm Drug Dispos. 43: 247-254. PMID: 36519186

订购信息

产品名称产品编号规格价格数量收藏夹

RKIP 抗体 (D-5)

sc-365973
200 µg/ml
$316.00

RKIP (D-5): m-IgG Fc BP-HRP 套装

sc-537860
200 µg Ab; 10 µg BP
$354.00

RKIP (D-5): m-IgGκ BP-HRP 套装

sc-535289
200 µg Ab; 40 µg BP
$354.00

RKIP (D-5): m-IgG1 BP-HRP 套装

sc-545410
200 µg Ab; 20 µg BP
$354.00

RKIP (D-5) 中和勝肽

sc-365973 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-365973 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Well-rounded antibody for RKIPThis antibody is a great choice for staining paraffin tissue sections and for Western blot, strong, clean and specific.
Date published: 2017-01-25
Rated 5 out of 5 by from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human adrenal gland tissue. -SCBT QC
Date published: 2015-05-11
Rated 5 out of 5 by from Good Western Blot data of RKIP expressionGood Western Blot data of RKIP expression in rat brain tissue extract. -SCBT QC
Date published: 2013-04-06
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RKIP 抗体 (D-5) is rated 5.0 out of 5 by 3.
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