Rho Kinase Inhibitor 抑制剂

物理状态 :

Solid

溶解度 :

Soluble in water, and methanol.

保存 :

Store at 4° C

沸点 :

562.6° C at 760 mmHg (Predicted)

折射率 :

n²⁰_D ~1.59 (Predicted)

IC50 :

lysophosphatidic acid-induced phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS: IC₅₀ = 2.5 µM (NT-2 cells)

Ki 数据 :

ROCK: K_i= 1.6 nM; PKA: K_i= 630 nM; PKC: K_i= 9.27 µM; MLCK: K_i= 10.1 µM

PubChem CID :

SMILES :

C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl