PTP Inhibitor III CAS: 29936-81-0
MF: C10H9BrO4
MW: 273.1
A cell-permeable compound that inhibits a broad-range of PTPs.

PTP Inhibitor III (CAS 29936-81-0)

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备用名: α-Bromo-4-(carboxymethoxy)acetophenone
应用; PTP Inhibitor III is a cell-permeable compound that inhibits a broad-range of PTPs
CAS号码: 29936-81-0
纯度: ≥90%
分子量: 273.1
分子式: C10H9BrO4
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

PTP inhibitor III is a cell-permeable compound that inhibits a broad-range of PTPs (protein tyrosine phosphatases). PTPs help balance the activation of signaling proteins in vascular cells and keep the cells functioning in a normal state. The compound binds with a higher affinity to the catalytic domain of the SH2 domain-containing phosphatase SHP-1 than the PTP I inhibitor.


参考文献

1. Kanda, M., et al. 2006. J. Biol. Chem. 281: 28518-28528. PMID: 16893901
2. Popov, D. 2009. Biochem. Biophys. Res. Commun. 389: 1-4. PMID: 19715673

物理状态 :
Solid
溶解度 :
Soluble in DMSO.
保存 :
Store at -80° C
IC50 :
PTP: IC50 = 193 µM
Ki 数据 :
SHP-1: Ki= 193 µM
仅供科研使用。不可用于诊断或治疗。
运输 :
UN 1759, Class 8, Packing group II
MDL 号码 :
MFCD01087714

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PMID: # 29708510  Ubil, E. et al. 2018. J. Clin. Invest. 128: 2356-2369.

PMID: # 23314616  Kim, EJ. et al. 2013. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 62: 377-86.

PMID: # 22288587  Lee, SM. et al. 2012. Clinical and experimental immunology. 167: 438-46.

PMID: # 22571339  Kim, JK. et al. 2012. Cancer investigation. 30: 364-71.

PMID: # 22403793  Annaba, F. et al. 2012. American journal of physiology. Gastrointestinal and liver physiology. 302: G1216-22.

PMID: # 21536801  Lee, SM. et al. 2011. Journal of immunology (Baltimore, Md. : 1950). 186: 6296-303.

PMID: # 21896016  Lee, SM. et al. 2011. Immunology. 134: 224-33.

PMID: # 20646006  Lee, SM. et al. 2010. Clinical and experimental immunology. 161: 504-11.

PMID: # 22043923  Immunology. 226-35.

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