PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt) MF: C25H46O16P2•2NH4
MW: 700.7

PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)

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分子量: 700.7
分子式: C25H46O16P22NH4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-(5)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(5)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphoinositol (PI)-specific kinases. Hydrolysis of PtdIns-(4,5)-P2 by PI-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.


参考文献

1. Exton, J.H. 1996. Annu. Rev. Pharmacol. Toxicol. 36: 481-509. PMID: 8725399
2. Majerus, P.W. 1992. Annu. Rev. Biochem. 61: 225-250. PMID: 1323235

外观 :
Lyophilized powder
物理状态 :
Solid
保存 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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